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Article: Adverse systemic arterial function in patients with selenium deficiency

TitleAdverse systemic arterial function in patients with selenium deficiency
Authors
Keywordsarterial stiffness
nutrition
secondary prevention
Selenium deficiency
vascular function
Issue Date2012
PublisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603
Citation
Journal Of Nutrition, Health And Aging, 2012, v. 16 n. 1, p. 85-88 How to Cite?
AbstractBackground: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins which might contribute to cardiovascular protection. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. Objective: To investigate for any relationship between selenium deficiency and systemic arterial function in patients with high risk of vascular events. Design: Cross-sectional study. Setting and Participants: 306 consecutive patients with high risk for cardiovascular events (coronary artery disease 35%, acute/recurrent ischemic stroke 40%, diabetes mellitus 54%) followed up at internal medicine outpatient clinics. Measurements: Non-invasive brachial-ankle pulse wave velocity (PWV) was determined using vascular profiling system (VP-2000). Long-term intake of selenium was determined by a validated food frequency questionnaire. Results: Mean daily selenium intake was 59.5 ± 52.1 mcg/day, and mean PWV was 1782.4 ± 418.4 cm/s. Patients with selenium intake <10th percentile had significantly higher PWV as compared to patients with intake 10th percentile (1968.2 ± 648.9 cm/s versus 1762.2 ± 381.6 cm/s, P=0.010). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake <10th percentile remained independently predictive of increased PWV by +363.4 cm/s [95% CI: 68.1 to 658.6, P=0.016, relative increase 21%]. Conclusions: Selenium deficiency is associated with adverse arterial function in patients with high risk for vascular events. © 2012 The Journal of Nutrition, Health & Aging.
Persistent Identifierhttp://hdl.handle.net/10722/134124
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, YHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorCheung, BMen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2011-06-13T07:19:50Z-
dc.date.available2011-06-13T07:19:50Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Nutrition, Health And Aging, 2012, v. 16 n. 1, p. 85-88en_HK
dc.identifier.issn1279-7707en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134124-
dc.description.abstractBackground: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins which might contribute to cardiovascular protection. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. Objective: To investigate for any relationship between selenium deficiency and systemic arterial function in patients with high risk of vascular events. Design: Cross-sectional study. Setting and Participants: 306 consecutive patients with high risk for cardiovascular events (coronary artery disease 35%, acute/recurrent ischemic stroke 40%, diabetes mellitus 54%) followed up at internal medicine outpatient clinics. Measurements: Non-invasive brachial-ankle pulse wave velocity (PWV) was determined using vascular profiling system (VP-2000). Long-term intake of selenium was determined by a validated food frequency questionnaire. Results: Mean daily selenium intake was 59.5 ± 52.1 mcg/day, and mean PWV was 1782.4 ± 418.4 cm/s. Patients with selenium intake <10th percentile had significantly higher PWV as compared to patients with intake 10th percentile (1968.2 ± 648.9 cm/s versus 1762.2 ± 381.6 cm/s, P=0.010). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake <10th percentile remained independently predictive of increased PWV by +363.4 cm/s [95% CI: 68.1 to 658.6, P=0.016, relative increase 21%]. Conclusions: Selenium deficiency is associated with adverse arterial function in patients with high risk for vascular events. © 2012 The Journal of Nutrition, Health & Aging.en_HK
dc.languageengen_US
dc.publisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603en_HK
dc.relation.ispartofJournal of Nutrition, Health and Agingen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectarterial stiffnessen_HK
dc.subjectnutritionen_HK
dc.subjectsecondary preventionen_HK
dc.subjectSelenium deficiencyen_HK
dc.subjectvascular functionen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnkle Brachial Indexen_HK
dc.subject.meshBlood Flow Velocityen_HK
dc.subject.meshBrachial Artery - physiopathologyen_HK
dc.subject.meshCardiovascular Diseases - etiologyen_HK
dc.subject.meshConfounding Factors (Epidemiology)en_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDeficiency Diseases - complications - physiopathologyen_HK
dc.subject.meshDiet Recordsen_HK
dc.subject.meshEnergy Intakeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNutrition Assessmenten_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshSelenium - administration & dosage - deficiencyen_HK
dc.subject.meshTrace Elements - deficiencyen_HK
dc.subject.meshVascular Diseases - etiology - physiopathologyen_HK
dc.titleAdverse systemic arterial function in patients with selenium deficiencyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1279-7707&volume=&spage=&epage=&date=2011&atitle=Adverse+systemic+arterial+function+in+patients+with+selenium+deficiency-
dc.identifier.emailChan, YH:chanwill@hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailCheung, BM:mycheung@hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityCheung, BM=rp01321en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s12603-011-0086-5en_HK
dc.identifier.pmid22238006-
dc.identifier.scopuseid_2-s2.0-84856361555en_HK
dc.identifier.hkuros194717-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856361555&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue1en_HK
dc.identifier.spage85en_HK
dc.identifier.epage88en_HK
dc.identifier.isiWOS:000300523500013-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridChan, YH=22633700600en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridChan, HT=22633582100en_HK
dc.identifier.scopusauthoridLi, SW=16319340200en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridCheung, BM=7103294806en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.issnl1279-7707-

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