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Article: Targeting glutamate synthase for tuberculosis drug development
Title | Targeting glutamate synthase for tuberculosis drug development |
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Authors | |
Issue Date | 2011 |
Publisher | Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/index.html |
Citation | Hong Kong Medical Journal, 2011, v. 17 n. Supp. 2, p. S32-34 How to Cite? |
Abstract | 1. The Mycobacterium tuberculosis glutamate synthase consisting of alpha and beta subunits can be purified in a heterologous Escherichia coli expression system. 2. The beta subunit can be expressed in the soluble protein fraction under low temperature conditions. 3. The alpha subunit enters inclusion bodies in E coli but can be refolded and subsequently purified. |
Persistent Identifier | http://hdl.handle.net/10722/133579 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
DC Field | Value | Language |
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dc.contributor.author | Cheung, YW | en_US |
dc.contributor.author | Tanner, JA | en_US |
dc.date.accessioned | 2011-05-24T02:11:13Z | - |
dc.date.available | 2011-05-24T02:11:13Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Hong Kong Medical Journal, 2011, v. 17 n. Supp. 2, p. S32-34 | en_US |
dc.identifier.issn | 1024-2708 | - |
dc.identifier.uri | http://hdl.handle.net/10722/133579 | - |
dc.description.abstract | 1. The Mycobacterium tuberculosis glutamate synthase consisting of alpha and beta subunits can be purified in a heterologous Escherichia coli expression system. 2. The beta subunit can be expressed in the soluble protein fraction under low temperature conditions. 3. The alpha subunit enters inclusion bodies in E coli but can be refolded and subsequently purified. | - |
dc.language | eng | en_US |
dc.publisher | Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/index.html | - |
dc.relation.ispartof | Hong Kong Medical Journal | en_US |
dc.rights | Hong Kong Medical Journal. Copyright © Hong Kong Medical Association. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Targeting glutamate synthase for tuberculosis drug development | en_US |
dc.type | Article | en_US |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=17&issue=Supp. 2&spage=S32&epage=34&date=2011&atitle=Targeting+glutamate+synthase+for+tuberculosis+drug+development | - |
dc.identifier.email | Tanner, JA: jatanner@hku.hk | en_US |
dc.identifier.authority | Tanner, JA=rp00495 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.hkuros | 185116 | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | Supp. 2 | - |
dc.identifier.spage | S32 | en_US |
dc.identifier.epage | 34 | en_US |
dc.identifier.issnl | 1024-2708 | - |