File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/0014-5793(88)80989-X
- Scopus: eid_2-s2.0-0024246450
- PMID: 2462514
- WOS: WOS:A1988R545300016
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Measurement of cytosolic free Ca2+ in individual pancreatic acini
Title | Measurement of cytosolic free Ca2+ in individual pancreatic acini |
---|---|
Authors | |
Keywords | Chemicals And Cas Registry Numbers |
Issue Date | 1988 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet |
Citation | Febs Letters, 1988, v. 242 n. 1, p. 79-84 How to Cite? |
Abstract | The kinetics of changes in cytosolic free Ca2+ ([Ca2+](i)) were determined in individual rat pancreatic acini by microfluorimetry. Three major findings are reported. First, at maximal stimulatory concentrations for amylase release, both caerulein and bombesin induced an initial rise in [Ca2+](i) followed by prolonged secondary oscillations of smaller amplitude. The latter effect was not observed with supramaximal doses of caerulein. Second, these cyclic changes were dependent, at least in part, on extracellular Ca2+. Finally, comparison of the threshold doses for [Ca2+](i) mobilization and enzyme discharge demonstrated that pathways independent of an elevation of [Ca2+](i) control the secretory activity of pancreatic acini at low, picomolar agonist concentrations. |
Persistent Identifier | http://hdl.handle.net/10722/132778 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 1.208 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pralong, WF | en_HK |
dc.contributor.author | Wollheim, CB | en_HK |
dc.contributor.author | Bruzzone, R | en_HK |
dc.date.accessioned | 2011-03-28T09:28:55Z | - |
dc.date.available | 2011-03-28T09:28:55Z | - |
dc.date.issued | 1988 | en_HK |
dc.identifier.citation | Febs Letters, 1988, v. 242 n. 1, p. 79-84 | en_HK |
dc.identifier.issn | 0014-5793 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/132778 | - |
dc.description.abstract | The kinetics of changes in cytosolic free Ca2+ ([Ca2+](i)) were determined in individual rat pancreatic acini by microfluorimetry. Three major findings are reported. First, at maximal stimulatory concentrations for amylase release, both caerulein and bombesin induced an initial rise in [Ca2+](i) followed by prolonged secondary oscillations of smaller amplitude. The latter effect was not observed with supramaximal doses of caerulein. Second, these cyclic changes were dependent, at least in part, on extracellular Ca2+. Finally, comparison of the threshold doses for [Ca2+](i) mobilization and enzyme discharge demonstrated that pathways independent of an elevation of [Ca2+](i) control the secretory activity of pancreatic acini at low, picomolar agonist concentrations. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet | en_HK |
dc.relation.ispartof | FEBS Letters | en_HK |
dc.subject | Chemicals And Cas Registry Numbers | en_US |
dc.title | Measurement of cytosolic free Ca2+ in individual pancreatic acini | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Bruzzone, R: bruzzone@hkucc.hku.hk | en_HK |
dc.identifier.authority | Bruzzone, R=rp01442 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-5793(88)80989-X | en_HK |
dc.identifier.pmid | 2462514 | - |
dc.identifier.scopus | eid_2-s2.0-0024246450 | en_HK |
dc.identifier.volume | 242 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 79 | en_HK |
dc.identifier.epage | 84 | en_HK |
dc.identifier.isi | WOS:A1988R545300016 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Pralong, WF=7004215911 | en_HK |
dc.identifier.scopusauthorid | Wollheim, CB=7103171309 | en_HK |
dc.identifier.scopusauthorid | Bruzzone, R=7006793327 | en_HK |
dc.identifier.issnl | 0014-5793 | - |