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- Publisher Website: 10.1016/j.bone.2008.08.112
- Scopus: eid_2-s2.0-67949097323
- PMID: 18778801
- WOS: WOS:000269378200021
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Article: Peri-graft bone mass and connectivity as predictors for the strength of tendon-to-bone attachment after anterior cruciate ligament reconstruction
Title | Peri-graft bone mass and connectivity as predictors for the strength of tendon-to-bone attachment after anterior cruciate ligament reconstruction | ||||
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Authors | |||||
Keywords | Anterior cruciate ligament (ACL) reconstruction Bone mass Micro-computed tomography (micro-CT) Microarchitecture Peripheral quantitative computed tomography (pQCT) | ||||
Issue Date | 2009 | ||||
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone | ||||
Citation | Bone, 2009, v. 45 n. 3, p. 545-552 How to Cite? | ||||
Abstract | The present study was designed to compare peri-graft bone mass and microarchitecture with tendon-to-bone (T-B) attachment strength after anterior cruciate ligament (ACL) reconstruction in a rabbit model. Surgical reconstruction using digital extensor tendon in bone tunnel was performed on 58 rabbits. Forty-two of the 58 rabbits were sacrificed at week 0, 2, 6 and 12 after operation respectively. The femur-graft-tibia complexes were harvested for pQCT and micro-CT examination to characterize the spatiotemporal changes of peri-graft bone in T-B healing in conjunction with histological examination. The remaining 16 rabbits were euthanized at week 6 and 12 postoperatively (i.e. 8 rabbits for each time point) for pull-out test after micro-CT examination to investigate the relationship between the T-B attachment strength and peri-graft bone mass/microarchitecture. Peri-graft BMD, BV/TV and connectivity was significantly lower at week 6 than those at time zero although there were no significant changes detected in the first 2 postoperative weeks. In addition, peri-graft bone mass and connectivity was significantly lower on the tibial side than those on the femoral side; and osteoclasts accumulated on the surface of peri-graft bone. Grafted tendon was prone to be pulled out from the tibial tunnel with bone attachment; the weakest point of the complexes shifted from the healing interface at time zero to peri-graft bone at week 6 after operation. With reverse of peri-graft bone at week 12 postoperatively, the weakest point shifted to the intra-osseous tendinous portion. The stiffness of T-B attachment correlated with peri-graft BV/TV (r2 = 0.68, p = 0.001) and connectivity (r2 = 0.47, p = 0.013) at week 6 after operation. T-B healing was a highly dynamic process of emergence and maintenance of peri-graft bone. T-B attachment strength was in relation to peri-graft bone mass and connectivity after ACL reconstruction. The measurement of peri-graft bone should be useful to monitor the quality of T-B healing and guide the postoperative rehabilitation. | ||||
Persistent Identifier | http://hdl.handle.net/10722/131078 | ||||
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.179 | ||||
ISI Accession Number ID |
Funding Information: This study is supported by the Research Grant Council Earmarked Grants 06-07 (CUHK4497/06M), Hong Kong SAR, China. The authors Would like to thank Margaret Wan-Nar Wong, Po-Yee Lui and Saichuen Fu who provided expertises at academic meetings as well as Hui-Yan Yeung, Chun-Wai Chan, Grace Ho and Anita Wai-Ting Shum who gave technical assistance. |
DC Field | Value | Language |
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dc.contributor.author | Wen, CY | - |
dc.contributor.author | Qin, L | - |
dc.contributor.author | Lee, KM | - |
dc.contributor.author | Chan, KM | - |
dc.date.accessioned | 2011-01-18T07:00:34Z | - |
dc.date.available | 2011-01-18T07:00:34Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Bone, 2009, v. 45 n. 3, p. 545-552 | - |
dc.identifier.issn | 8756-3282 | - |
dc.identifier.uri | http://hdl.handle.net/10722/131078 | - |
dc.description.abstract | The present study was designed to compare peri-graft bone mass and microarchitecture with tendon-to-bone (T-B) attachment strength after anterior cruciate ligament (ACL) reconstruction in a rabbit model. Surgical reconstruction using digital extensor tendon in bone tunnel was performed on 58 rabbits. Forty-two of the 58 rabbits were sacrificed at week 0, 2, 6 and 12 after operation respectively. The femur-graft-tibia complexes were harvested for pQCT and micro-CT examination to characterize the spatiotemporal changes of peri-graft bone in T-B healing in conjunction with histological examination. The remaining 16 rabbits were euthanized at week 6 and 12 postoperatively (i.e. 8 rabbits for each time point) for pull-out test after micro-CT examination to investigate the relationship between the T-B attachment strength and peri-graft bone mass/microarchitecture. Peri-graft BMD, BV/TV and connectivity was significantly lower at week 6 than those at time zero although there were no significant changes detected in the first 2 postoperative weeks. In addition, peri-graft bone mass and connectivity was significantly lower on the tibial side than those on the femoral side; and osteoclasts accumulated on the surface of peri-graft bone. Grafted tendon was prone to be pulled out from the tibial tunnel with bone attachment; the weakest point of the complexes shifted from the healing interface at time zero to peri-graft bone at week 6 after operation. With reverse of peri-graft bone at week 12 postoperatively, the weakest point shifted to the intra-osseous tendinous portion. The stiffness of T-B attachment correlated with peri-graft BV/TV (r2 = 0.68, p = 0.001) and connectivity (r2 = 0.47, p = 0.013) at week 6 after operation. T-B healing was a highly dynamic process of emergence and maintenance of peri-graft bone. T-B attachment strength was in relation to peri-graft bone mass and connectivity after ACL reconstruction. The measurement of peri-graft bone should be useful to monitor the quality of T-B healing and guide the postoperative rehabilitation. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone | - |
dc.relation.ispartof | Bone | - |
dc.subject | Anterior cruciate ligament (ACL) reconstruction | - |
dc.subject | Bone mass | - |
dc.subject | Micro-computed tomography (micro-CT) | - |
dc.subject | Microarchitecture | - |
dc.subject | Peripheral quantitative computed tomography (pQCT) | - |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Anterior Cruciate Ligament - surgery | - |
dc.subject.mesh | Femur - physiology | - |
dc.subject.mesh | Tendons - physiology - transplantation | - |
dc.subject.mesh | Tibia - physiology | - |
dc.title | Peri-graft bone mass and connectivity as predictors for the strength of tendon-to-bone attachment after anterior cruciate ligament reconstruction | en_US |
dc.type | Article | en_US |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=8756-3282&volume=45&issue=3&spage=545&epage=552&date=2009&atitle=Peri-graft+bone+mass+and+connectivity+as+predictors+for+the+strength+of+tendon-to-bone+attachment+after+anterior+cruciate+ligament+reconstruction | - |
dc.identifier.email | Wen, CY: paulwen@hku.hk,wenchunyi@ort.cuhk.edu.hk | - |
dc.identifier.email | Chan, KM: kaimingchan@cuhk.edu.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bone.2008.08.112 | - |
dc.identifier.pmid | 18778801 | - |
dc.identifier.scopus | eid_2-s2.0-67949097323 | - |
dc.identifier.hkuros | 174676 | - |
dc.identifier.hkuros | 188833 | - |
dc.identifier.volume | 45 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 545 | - |
dc.identifier.epage | 552 | - |
dc.identifier.isi | WOS:000269378200021 | - |
dc.identifier.citeulike | 5492922 | - |
dc.identifier.issnl | 1873-2763 | - |