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Article: Spatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injury
Title | Spatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injury | ||||
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Authors | |||||
Keywords | affective amygdala anterior cingulate cortex Neuropathic pain NF-κB somatosensory cortex thalamus | ||||
Issue Date | 2011 | ||||
Publisher | Churchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jpain | ||||
Citation | Journal Of Pain, 2011, v. 12 n. 1, p. 13-21 How to Cite? | ||||
Abstract | The expression of NF-κB in the spinal cord is associated with neuropathic pain. However, little is known about its expression beyond the spinal cord. Here we examined a spatial and temporal pattern of the NF-κB expression in both spinal and supraspinal regions. After chronic constriction injury (CCI) of the sciatic nerve, NF-κB (p65) expression was significantly increased in the ipsilateral spinal cord. In contrast, the NF-κB expression in the contralateral primary somatosensory cortex was decreased with no significant differences seen in the thalamus. In the contralateral anterior cingulate cortex, the NF-κB expression was increased significantly on day 14 as compared with the sham group. In the contralateral amygdala, the NF-κB expression showed a time-dependent downregulation after CCI, which became significant on day 14. MK-801 reduced nociceptive behaviors and reversed the direction of NF-κB expression. These results indicate that the CCI-induced expression of p65 NF-κB is both time-dependent and region-specific, in areas that process both sensory-discriminative and motivational-affective dimensions of pain. Perspective: This article presents a spatiotemporal mapping of the NF-κB expression in spinal and supraspinal regions after peripheral nerve injury. These findings point to an involvement of NF-κB beyond the spinal cord in both the sensory discriminative and emotional affective aspects of neuropathic pain processing. © 2011 by the American Pain Society. | ||||
Persistent Identifier | http://hdl.handle.net/10722/129083 | ||||
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.339 | ||||
PubMed Central ID | |||||
ISI Accession Number ID |
Funding Information: Supported by NIH RO1 grants DE18214, DE18538, and NS45681. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chou, CW | en_HK |
dc.contributor.author | Wong, GTC | en_HK |
dc.contributor.author | Lim, G | en_HK |
dc.contributor.author | Wang, S | en_HK |
dc.contributor.author | Irwin, MG | en_HK |
dc.contributor.author | Mao, J | en_HK |
dc.date.accessioned | 2010-12-23T08:32:15Z | - |
dc.date.available | 2010-12-23T08:32:15Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Journal Of Pain, 2011, v. 12 n. 1, p. 13-21 | en_HK |
dc.identifier.issn | 1526-5900 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/129083 | - |
dc.description.abstract | The expression of NF-κB in the spinal cord is associated with neuropathic pain. However, little is known about its expression beyond the spinal cord. Here we examined a spatial and temporal pattern of the NF-κB expression in both spinal and supraspinal regions. After chronic constriction injury (CCI) of the sciatic nerve, NF-κB (p65) expression was significantly increased in the ipsilateral spinal cord. In contrast, the NF-κB expression in the contralateral primary somatosensory cortex was decreased with no significant differences seen in the thalamus. In the contralateral anterior cingulate cortex, the NF-κB expression was increased significantly on day 14 as compared with the sham group. In the contralateral amygdala, the NF-κB expression showed a time-dependent downregulation after CCI, which became significant on day 14. MK-801 reduced nociceptive behaviors and reversed the direction of NF-κB expression. These results indicate that the CCI-induced expression of p65 NF-κB is both time-dependent and region-specific, in areas that process both sensory-discriminative and motivational-affective dimensions of pain. Perspective: This article presents a spatiotemporal mapping of the NF-κB expression in spinal and supraspinal regions after peripheral nerve injury. These findings point to an involvement of NF-κB beyond the spinal cord in both the sensory discriminative and emotional affective aspects of neuropathic pain processing. © 2011 by the American Pain Society. | en_HK |
dc.language | eng | en_US |
dc.publisher | Churchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jpain | en_HK |
dc.relation.ispartof | Journal of Pain | en_HK |
dc.rights | A definitive version was published in The Journal of Pain, 2011, v. 12 n. 1, p. 13-21. DOI: 10.1016/j.jpain.2010.03.018 | - |
dc.subject | affective | en_HK |
dc.subject | amygdala | en_HK |
dc.subject | anterior cingulate cortex | en_HK |
dc.subject | Neuropathic pain | en_HK |
dc.subject | NF-κB | en_HK |
dc.subject | somatosensory cortex | en_HK |
dc.subject | thalamus | en_HK |
dc.subject.mesh | Gene Expression Regulation - drug effects - physiology | - |
dc.subject.mesh | NF-kappa B - metabolism | - |
dc.subject.mesh | Peripheral Nervous System Diseases - complications - metabolism - pathology | - |
dc.subject.mesh | Somatosensory Cortex - metabolism | - |
dc.subject.mesh | Spinal Cord - metabolism | - |
dc.title | Spatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injury | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1526-5900&volume=12&issue=1&spage=13&epage=21&date=2011&atitle=Spatiotemporal+pattern+of+concurrent+spinal+and+supraspinal+NF-κB+expression+after+peripheral+nerve+injury | - |
dc.identifier.email | Wong, GTC:gordon@hku.hk | en_HK |
dc.identifier.email | Irwin, MG:mgirwin@hku.hk | en_HK |
dc.identifier.authority | Wong, GTC=rp00523 | en_HK |
dc.identifier.authority | Irwin, MG=rp00390 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.jpain.2010.03.018 | en_HK |
dc.identifier.pmid | 20537956 | - |
dc.identifier.pmcid | PMC2978259 | - |
dc.identifier.scopus | eid_2-s2.0-78650709698 | en_HK |
dc.identifier.hkuros | 184513 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78650709698&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 12 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 13 | en_HK |
dc.identifier.epage | 21 | en_HK |
dc.identifier.eissn | 1528-8447 | - |
dc.identifier.isi | WOS:000286549700003 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.issnl | 1526-5900 | - |