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- Publisher Website: 10.1038/leu.2009.33
- Scopus: eid_2-s2.0-68749120703
- PMID: 19262598
- WOS: WOS:000268862000017
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Article: New insights to the MLL recombinome of acute leukemias
Title | New insights to the MLL recombinome of acute leukemias | ||||||||
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Authors | Meyer, CKowarz, EHofmann, JRenneville, AZuna, JTrka, JBen Abdelali, RMacintyre, EDe Braekeleer, EDe Braekeleer, MDelabesse, Ede Oliveira, MPCavé, HClappier, Evan Dongen, JJMBalgobind, BVvan den HeuvelEibrink, MMBeverloo, HBPanzerGrümayer, RTeiglerSchlegel, AHarbott, JKjeldsen, ESchnittger, SKoehl, UGruhn, BHeidenreich, OChan, LCYip, SFKrzywinski, MEckert, CMöricke, ASchrappe, MAlonso, CNSchäfer, BWKrauter, JLee, DAzur Stadt, UTe Kronnie, GSutton, RIzraeli, STrakhtenbrot, LLo Nigro, LTsaur, GFechina, LSzczepanski, TStrehl, SIlencikova, DMolkentin, MBurmeister, TDingermann, TKlingebiel, TMarschalek, R | ||||||||
Issue Date | 2009 | ||||||||
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/leu | ||||||||
Citation | Leukemia, 2009, v. 23 n. 8, p. 1490-1499 How to Cite? | ||||||||
Abstract | Chromosomal rearrangements of the human MLL gene are associated with high-risk pediatric, adult and therapy-associated acute leukemias. These patients need to be identified, treated appropriately and minimal residual disease was monitored by quantitative PCR techniques. Genomic DNA was isolated from individual acute leukemia patients to identify and characterize chromosomal rearrangements involving the human MLL gene. A total of 760 MLL-rearranged biopsy samples obtained from 384 pediatric and 376 adult leukemia patients were characterized at the molecular level. The distribution of MLL breakpoints for clinical subtypes (acute lymphoblastic leukemia, acute myeloid leukemia, pediatric and adult) and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes. Combined data of our study and recently published data revealed 104 different MLL rearrangements of which 64 TPGs are now characterized on the molecular level. Nine TPGs seem to be predominantly involved in genetic recombinations of MLL: AFF1/AF4, MLLT3/ AF9, MLLT1/ENL, MLLT10/AF10, MLLT4/AF6, ELL, EPS15/AF1P, MLLT6/AF17 and SEPT6, respectively. Moreover, we describe for the first time the genetic network of reciprocal MLL gene fusions deriving from complex rearrangements. | ||||||||
Persistent Identifier | http://hdl.handle.net/10722/126723 | ||||||||
ISSN | 2023 Impact Factor: 12.8 2023 SCImago Journal Rankings: 3.662 | ||||||||
ISI Accession Number ID |
Funding Information: This work was made possible by and conducted within the framework of the International BFM Study Group. This study was supported by grant 107819 from the Deutsche Krebshilfe to RM, TD and TK; supported by grant R06/22 from the German Jose Carreras Leukemia foundation to TB and supported by grant 2 P054 095 30 from the Polish Ministry of Science and Higher Education to TS. | ||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Meyer, C | en_HK |
dc.contributor.author | Kowarz, E | en_HK |
dc.contributor.author | Hofmann, J | en_HK |
dc.contributor.author | Renneville, A | en_HK |
dc.contributor.author | Zuna, J | en_HK |
dc.contributor.author | Trka, J | en_HK |
dc.contributor.author | Ben Abdelali, R | en_HK |
dc.contributor.author | Macintyre, E | en_HK |
dc.contributor.author | De Braekeleer, E | en_HK |
dc.contributor.author | De Braekeleer, M | en_HK |
dc.contributor.author | Delabesse, E | en_HK |
dc.contributor.author | de Oliveira, MP | en_HK |
dc.contributor.author | Cavé, H | en_HK |
dc.contributor.author | Clappier, E | en_HK |
dc.contributor.author | van Dongen, JJM | en_HK |
dc.contributor.author | Balgobind, BV | en_HK |
dc.contributor.author | van den HeuvelEibrink, MM | en_HK |
dc.contributor.author | Beverloo, HB | en_HK |
dc.contributor.author | PanzerGrümayer, R | en_HK |
dc.contributor.author | TeiglerSchlegel, A | en_HK |
dc.contributor.author | Harbott, J | en_HK |
dc.contributor.author | Kjeldsen, E | en_HK |
dc.contributor.author | Schnittger, S | en_HK |
dc.contributor.author | Koehl, U | en_HK |
dc.contributor.author | Gruhn, B | en_HK |
dc.contributor.author | Heidenreich, O | en_HK |
dc.contributor.author | Chan, LC | en_HK |
dc.contributor.author | Yip, SF | en_HK |
dc.contributor.author | Krzywinski, M | en_HK |
dc.contributor.author | Eckert, C | en_HK |
dc.contributor.author | Möricke, A | en_HK |
dc.contributor.author | Schrappe, M | en_HK |
dc.contributor.author | Alonso, CN | en_HK |
dc.contributor.author | Schäfer, BW | en_HK |
dc.contributor.author | Krauter, J | en_HK |
dc.contributor.author | Lee, DA | en_HK |
dc.contributor.author | zur Stadt, U | en_HK |
dc.contributor.author | Te Kronnie, G | en_HK |
dc.contributor.author | Sutton, R | en_HK |
dc.contributor.author | Izraeli, S | en_HK |
dc.contributor.author | Trakhtenbrot, L | en_HK |
dc.contributor.author | Lo Nigro, L | en_HK |
dc.contributor.author | Tsaur, G | en_HK |
dc.contributor.author | Fechina, L | en_HK |
dc.contributor.author | Szczepanski, T | en_HK |
dc.contributor.author | Strehl, S | en_HK |
dc.contributor.author | Ilencikova, D | en_HK |
dc.contributor.author | Molkentin, M | en_HK |
dc.contributor.author | Burmeister, T | en_HK |
dc.contributor.author | Dingermann, T | en_HK |
dc.contributor.author | Klingebiel, T | en_HK |
dc.contributor.author | Marschalek, R | en_HK |
dc.date.accessioned | 2010-10-31T12:44:45Z | - |
dc.date.available | 2010-10-31T12:44:45Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Leukemia, 2009, v. 23 n. 8, p. 1490-1499 | en_HK |
dc.identifier.issn | 0887-6924 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/126723 | - |
dc.description.abstract | Chromosomal rearrangements of the human MLL gene are associated with high-risk pediatric, adult and therapy-associated acute leukemias. These patients need to be identified, treated appropriately and minimal residual disease was monitored by quantitative PCR techniques. Genomic DNA was isolated from individual acute leukemia patients to identify and characterize chromosomal rearrangements involving the human MLL gene. A total of 760 MLL-rearranged biopsy samples obtained from 384 pediatric and 376 adult leukemia patients were characterized at the molecular level. The distribution of MLL breakpoints for clinical subtypes (acute lymphoblastic leukemia, acute myeloid leukemia, pediatric and adult) and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes. Combined data of our study and recently published data revealed 104 different MLL rearrangements of which 64 TPGs are now characterized on the molecular level. Nine TPGs seem to be predominantly involved in genetic recombinations of MLL: AFF1/AF4, MLLT3/ AF9, MLLT1/ENL, MLLT10/AF10, MLLT4/AF6, ELL, EPS15/AF1P, MLLT6/AF17 and SEPT6, respectively. Moreover, we describe for the first time the genetic network of reciprocal MLL gene fusions deriving from complex rearrangements. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/leu | en_HK |
dc.relation.ispartof | Leukemia | en_HK |
dc.subject.mesh | Acute Disease | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Biopsy | en_HK |
dc.subject.mesh | Bone Marrow - chemistry - pathology | en_HK |
dc.subject.mesh | Child | en_HK |
dc.subject.mesh | Chromosome Breakage | en_HK |
dc.subject.mesh | Chromosomes, Human, Pair 11 - genetics - ultrastructure | en_HK |
dc.subject.mesh | Computational Biology | en_HK |
dc.subject.mesh | DNA, Neoplasm - blood - genetics | en_HK |
dc.subject.mesh | Gene Duplication | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Leukemia - genetics | en_HK |
dc.subject.mesh | Myeloid-Lymphoid Leukemia Protein - genetics | en_HK |
dc.subject.mesh | Neoplasm Proteins - genetics | en_HK |
dc.subject.mesh | Oncogene Proteins, Fusion - genetics | en_HK |
dc.subject.mesh | Polymerase Chain Reaction | en_HK |
dc.subject.mesh | Recombination, Genetic | en_HK |
dc.subject.mesh | Translocation, Genetic | en_HK |
dc.title | New insights to the MLL recombinome of acute leukemias | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0887-6924&volume=23&issue=8&spage=1490&epage=1499&date=2009&atitle=New+insights+to+the+MLL+recombinome+of+acute+leukemias | en_HK |
dc.identifier.email | Chan, LC:chanlc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, LC=rp00373 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/leu.2009.33 | en_HK |
dc.identifier.pmid | 19262598 | - |
dc.identifier.scopus | eid_2-s2.0-68749120703 | en_HK |
dc.identifier.hkuros | 181199 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-68749120703&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 23 | en_HK |
dc.identifier.issue | 8 | en_HK |
dc.identifier.spage | 1490 | en_HK |
dc.identifier.epage | 1499 | en_HK |
dc.identifier.isi | WOS:000268862000017 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.citeulike | 4141695 | - |
dc.identifier.issnl | 0887-6924 | - |