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Article: Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile

TitleHighly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile
Authors
Xue, HLu, XZheng, PLiu, LHan, CHu, JLiu, ZMa, TLi, YWang, LChen, ZLiu, G
Issue Date2010
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jmc
Citation
Journal Of Medicinal Chemistry, 2010, v. 53 n. 3, p. 1397-1401 How to Cite?
DOI: http://dx.doi.org/10.1021/jm901653e
AbstractWe herein report a new compound: 10-chloromethyl-11-demethyl-12-oxo- calanolide A (20, EC 50 = 7.4 nM, SI = 1417), which demonstrates a druggable profile with 32.7% oral bioavailability in rat, tolerated oral single dose toxicity in mice, and especially the feature of highly efficient suppression of the wild-type HIV-1 and Y181C mutant HIV-1 at an EC 50 = 7.4 nM and EC 50 = 0.46 nM, respectively. © 2010 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/125128
ISSN
0022-2623
2023 Impact Factor: 6.8
2023 SCImago Journal Rankings: 1.986
ISI Accession Number ID
WOS:000274270900045
Funding AgencyGrant Number
National Natural Science Foundation of China90713045
National 863 Program of China2006AA020501
HKU-UDF
HKSARGFHB/RFCID09080772
Funding Information:

This research is supported financially by the National Natural Science Foundation of China (No, 90713045) and the National 863 Program of China, No.2006AA020501. We thank HKU-UDF and HKSARG FHB/RFCID09080772 for partial funding support of this study. We are also grateful to Mr. Jinfeng Wei for his assistance of single dose toxicity measurement.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorXue, Hen_HK
dc.contributor.authorLu, Xen_HK
dc.contributor.authorZheng, Pen_HK
dc.contributor.authorLiu, Len_HK
dc.contributor.authorHan, Cen_HK
dc.contributor.authorHu, Jen_HK
dc.contributor.authorLiu, Zen_HK
dc.contributor.authorMa, Ten_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorChen, Zen_HK
dc.contributor.authorLiu, Gen_HK
dc.date.accessioned2010-10-31T11:12:58Z-
dc.date.available2010-10-31T11:12:58Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Medicinal Chemistry, 2010, v. 53 n. 3, p. 1397-1401en_HK
dc.identifier.issn0022-2623en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125128-
dc.description.abstractWe herein report a new compound: 10-chloromethyl-11-demethyl-12-oxo- calanolide A (20, EC 50 = 7.4 nM, SI = 1417), which demonstrates a druggable profile with 32.7% oral bioavailability in rat, tolerated oral single dose toxicity in mice, and especially the feature of highly efficient suppression of the wild-type HIV-1 and Y181C mutant HIV-1 at an EC 50 = 7.4 nM and EC 50 = 0.46 nM, respectively. © 2010 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jmcen_HK
dc.relation.ispartofJournal of Medicinal Chemistryen_HK
dc.subject.meshAnti-HIV Agents - chemical synthesis - chemistry - pharmacology-
dc.subject.meshHIV Infections - drug therapy - genetics-
dc.subject.meshHIV-1 - drug effects - genetics-
dc.subject.meshPyranocoumarins - chemical synthesis - chemistry - pharmacology-
dc.subject.meshVirus Replication - drug effects - genetics-
dc.titleHighly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profileen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2623&volume=53&issue=3&spage=1397&epage=1401&date=2010&atitle=Highly+suppressing+wild-type+HIV-1+and+Y181C+mutant+HIV-1+strains+by+10-chloromethyl-11-demethyl-12-oxo-calanolide+A+with+druggable+profile-
dc.identifier.emailLiu, L: liuli71@hkucc.hku.hken_HK
dc.identifier.emailChen, Z: zchenai@hku.hken_HK
dc.identifier.authorityLiu, L=rp00268en_HK
dc.identifier.authorityChen, Z=rp00243en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jm901653een_HK
dc.identifier.pmid20050672-
dc.identifier.scopuseid_2-s2.0-77249123906en_HK
dc.identifier.hkuros175959en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77249123906&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage1397en_HK
dc.identifier.epage1401en_HK
dc.identifier.isiWOS:000274270900045-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXue, H=35084707100en_HK
dc.identifier.scopusauthoridLu, X=35215493700en_HK
dc.identifier.scopusauthoridZheng, P=35764140600en_HK
dc.identifier.scopusauthoridLiu, L=35784425200en_HK
dc.identifier.scopusauthoridHan, C=17345759200en_HK
dc.identifier.scopusauthoridHu, J=23970787600en_HK
dc.identifier.scopusauthoridLiu, Z=35215529100en_HK
dc.identifier.scopusauthoridMa, T=35763830600en_HK
dc.identifier.scopusauthoridLi, Y=35187394200en_HK
dc.identifier.scopusauthoridWang, L=15836048000en_HK
dc.identifier.scopusauthoridChen, Z=35271180800en_HK
dc.identifier.scopusauthoridLiu, G=36077582900en_HK
dc.identifier.issnl0022-2623-

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