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- Publisher Website: 10.1177/1534735410373921
- Scopus: eid_2-s2.0-79953728787
- PMID: 20702496
- WOS: WOS:000289157000009
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Article: Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression
Title | Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression |
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Authors | |
Keywords | apoptosis doxorubicin Fructus Ligustri Lucidi sensitivity |
Issue Date | 2011 |
Publisher | Sage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510 |
Citation | Integrative Cancer Therapies, 2011, v. 10 n. 1, p. 85-91 How to Cite? |
Abstract | Chemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14 ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. © The Author(s) 2011. |
Persistent Identifier | http://hdl.handle.net/10722/124531 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.687 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, JF | en_HK |
dc.contributor.author | He, ML | en_HK |
dc.contributor.author | Dong, Q | en_HK |
dc.contributor.author | Xie, WD | en_HK |
dc.contributor.author | Chen, YC | en_HK |
dc.contributor.author | Lin, MCM | en_HK |
dc.contributor.author | Leung, PC | en_HK |
dc.contributor.author | Zhang, YO | en_HK |
dc.contributor.author | Kung, HF | en_HK |
dc.date.accessioned | 2010-10-31T10:39:44Z | - |
dc.date.available | 2010-10-31T10:39:44Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Integrative Cancer Therapies, 2011, v. 10 n. 1, p. 85-91 | en_HK |
dc.identifier.issn | 1534-7354 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/124531 | - |
dc.description.abstract | Chemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14 ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. © The Author(s) 2011. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Sage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510 | en_HK |
dc.relation.ispartof | Integrative Cancer Therapies | en_HK |
dc.rights | Integrative Cancer Therapies. Copyright © Sage Publications, Inc.. | - |
dc.subject | apoptosis | en_HK |
dc.subject | doxorubicin | en_HK |
dc.subject | Fructus Ligustri Lucidi | en_HK |
dc.subject | sensitivity | en_HK |
dc.title | Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1534-7354&volume=9&issue=4&spage=354&epage=364&date=2010&atitle=Aqueous+Extracts+of+Fructus+Ligustri+Lucidi+Enhance+the+Sensitivity+of+Human+Colorectal+Carcionma+DLD-1+Cells+to+Doxorubicin-Induced+Apoptosis+via+Tbx3+Suppression | en_HK |
dc.identifier.email | Lin, MCM:mcllin@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lin, MCM=rp00746 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1177/1534735410373921 | en_HK |
dc.identifier.pmid | 20702496 | - |
dc.identifier.scopus | eid_2-s2.0-79953728787 | en_HK |
dc.identifier.hkuros | 181309 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79953728787&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 10 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 85 | en_HK |
dc.identifier.epage | 91 | en_HK |
dc.identifier.isi | WOS:000289157000009 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Zhang, JF=13007942600 | en_HK |
dc.identifier.scopusauthorid | He, ML=35080389700 | en_HK |
dc.identifier.scopusauthorid | Dong, Q=37033806100 | en_HK |
dc.identifier.scopusauthorid | Xie, WD=35081557300 | en_HK |
dc.identifier.scopusauthorid | Chen, YC=7601431852 | en_HK |
dc.identifier.scopusauthorid | Lin, MCM=7404816359 | en_HK |
dc.identifier.scopusauthorid | Leung, PC=7401747829 | en_HK |
dc.identifier.scopusauthorid | Zhang, YO=47861579300 | en_HK |
dc.identifier.scopusauthorid | Kung, HF=7402514190 | en_HK |
dc.identifier.issnl | 1534-7354 | - |