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- PMID: 15633459
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Article: Involvement of cAMP in neuronal survival and axonal regeneration
Title | Involvement of cAMP in neuronal survival and axonal regeneration |
---|---|
Authors | |
Keywords | Axonal regeneration cAMP Central nervous system Neuronal survival |
Issue Date | 2004 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ASI |
Citation | Anatomical Science International, 2004, v. 79 n. 4, p. 209-212 How to Cite? |
Abstract | In vitro, cAMP elevation alters neuronal responsiveness to diffusible growth factors and overcomes myelin-associated inhibitory molecules. Significant advances have been made recently in understanding the role of increases in cAMP in promoting axonal growth. Importantly, it has now been shown that cAMP elevation can promote axonal regeneration and functional recovery after central nervous system injury. Elevation of cAMP can be achieved via either direct application of cAMP analogs or an inhibitor of the enzyme phosphodiesterase that degrades cAMP in vivo. Current information points to a number of protein kinase A-mediated pathways (mitogen-activated protein kinase/extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/akt pathway activation and Rho inactivation) underlying cAMP elevation-induced neuronal survival and axonal regeneration. |
Persistent Identifier | http://hdl.handle.net/10722/117943 |
ISSN | 2023 Impact Factor: 1.2 2023 SCImago Journal Rankings: 0.375 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cui, Q | en_HK |
dc.contributor.author | So, KF | en_HK |
dc.date.accessioned | 2010-09-26T07:41:14Z | - |
dc.date.available | 2010-09-26T07:41:14Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | Anatomical Science International, 2004, v. 79 n. 4, p. 209-212 | en_HK |
dc.identifier.issn | 1447-6959 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/117943 | - |
dc.description.abstract | In vitro, cAMP elevation alters neuronal responsiveness to diffusible growth factors and overcomes myelin-associated inhibitory molecules. Significant advances have been made recently in understanding the role of increases in cAMP in promoting axonal growth. Importantly, it has now been shown that cAMP elevation can promote axonal regeneration and functional recovery after central nervous system injury. Elevation of cAMP can be achieved via either direct application of cAMP analogs or an inhibitor of the enzyme phosphodiesterase that degrades cAMP in vivo. Current information points to a number of protein kinase A-mediated pathways (mitogen-activated protein kinase/extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/akt pathway activation and Rho inactivation) underlying cAMP elevation-induced neuronal survival and axonal regeneration. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ASI | en_HK |
dc.relation.ispartof | Anatomical Science International | en_HK |
dc.subject | Axonal regeneration | - |
dc.subject | cAMP | - |
dc.subject | Central nervous system | - |
dc.subject | Neuronal survival | - |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Antimicrobial Cationic Peptides - metabolism | en_HK |
dc.subject.mesh | Axons - metabolism | en_HK |
dc.subject.mesh | Cathelicidins | en_HK |
dc.subject.mesh | Cell Survival - physiology | en_HK |
dc.subject.mesh | Cells, Cultured | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Nerve Regeneration - physiology | en_HK |
dc.title | Involvement of cAMP in neuronal survival and axonal regeneration | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1447-6959&volume=79&issue=4&spage=209&epage=212&date=2004&atitle=Involvement+of+cAMP+in+neuronal+survival+and+axonal+regeneration | en_HK |
dc.identifier.email | So, KF:hrmaskf@hkucc.hku.hk | en_HK |
dc.identifier.authority | So, KF=rp00329 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 15633459 | - |
dc.identifier.scopus | eid_2-s2.0-10944220829 | en_HK |
dc.identifier.hkuros | 96918 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-10944220829&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 79 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 209 | en_HK |
dc.identifier.epage | 212 | en_HK |
dc.publisher.place | Australia | en_HK |
dc.identifier.scopusauthorid | Cui, Q=7103080164 | en_HK |
dc.identifier.scopusauthorid | So, KF=34668391300 | en_HK |
dc.identifier.issnl | 1447-073X | - |