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Conference Paper: C-Type Natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation in porcine coronary artery

TitleC-Type Natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation in porcine coronary artery
Authors
Ng, JKFLeung, SWSMan, RYKVanhoutte, PMGR
Issue Date2008
PublisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtl
Citation
The 2008 Annual Meeting of Experimental Biology (EB 2008) - ASPET's Centennial Meeting, San Diego, CA., 5-9 April 2008. In The FASEB Journal, 2008, v. 22 meeting abstract suppl., no. 914.3 How to Cite?
AbstractObjective: The release of CNP accounts for EDHF-mediated relaxations in the rat mesenteric artery1 and is Gi protein dependent2. EDHF-mediated relaxations in the porcine coronary artery are not Gi dependent3. This study investigates whether or not CNP release accounts for EDHF-responses in this artery. Methods: (1) CNP concentration was measured by enzyme immunoassay in bathing solution containing porcine coronary arterial rings where EDHF response was initiated by bradykinin (100 nM). (2) EDHF-mediated relaxations induced by SFLLRN were compared with those to exogenous CNP in the presence of phosphoramidon (10 µM; known to potentiate CNP induced relaxations). Results: There was no significant difference in the CNP concentrations between chambers containing rings that did or did not exhibit a EDHF-mediated response. Relaxations induced by CNP alone were potentiated by phosphoramidon (maximal relaxation 60.7 ± 7.7 % vs 84.1 ± 7.5 %, control vs phosphoramidon, P<0.05) but the EDHF-mediated responses to SFLLRN were not (maximal relaxation 69.9 ± 9.1 % vs 72.8 ± 9.9 %, control vs phosphoramidon) Conclusions: Unlike in the mesenteric artery and the heart of the rat, CNP release does not contribute to EDHF-mediated relaxations in the porcine coronary artery. FOOTNOTES Support: HKU CRCG (No. 21374077) REFERENCES Villar , et al. Cardiovasc Res 2007914.3 Chauhan , et al. PNAS 2003914.3 Ng , et al. J Vasc Res 200512 S2010
Persistent Identifierhttp://hdl.handle.net/10722/112777
ISSN
0892-6638
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 1.412

 

DC FieldValueLanguage
dc.contributor.authorNg, JKFen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorVanhoutte, PMGRen_HK
dc.date.accessioned2010-09-26T03:46:45Z-
dc.date.available2010-09-26T03:46:45Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 2008 Annual Meeting of Experimental Biology (EB 2008) - ASPET's Centennial Meeting, San Diego, CA., 5-9 April 2008. In The FASEB Journal, 2008, v. 22 meeting abstract suppl., no. 914.3-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/112777-
dc.description.abstractObjective: The release of CNP accounts for EDHF-mediated relaxations in the rat mesenteric artery1 and is Gi protein dependent2. EDHF-mediated relaxations in the porcine coronary artery are not Gi dependent3. This study investigates whether or not CNP release accounts for EDHF-responses in this artery. Methods: (1) CNP concentration was measured by enzyme immunoassay in bathing solution containing porcine coronary arterial rings where EDHF response was initiated by bradykinin (100 nM). (2) EDHF-mediated relaxations induced by SFLLRN were compared with those to exogenous CNP in the presence of phosphoramidon (10 µM; known to potentiate CNP induced relaxations). Results: There was no significant difference in the CNP concentrations between chambers containing rings that did or did not exhibit a EDHF-mediated response. Relaxations induced by CNP alone were potentiated by phosphoramidon (maximal relaxation 60.7 ± 7.7 % vs 84.1 ± 7.5 %, control vs phosphoramidon, P<0.05) but the EDHF-mediated responses to SFLLRN were not (maximal relaxation 69.9 ± 9.1 % vs 72.8 ± 9.9 %, control vs phosphoramidon) Conclusions: Unlike in the mesenteric artery and the heart of the rat, CNP release does not contribute to EDHF-mediated relaxations in the porcine coronary artery. FOOTNOTES Support: HKU CRCG (No. 21374077) REFERENCES Villar , et al. Cardiovasc Res 2007914.3 Chauhan , et al. PNAS 2003914.3 Ng , et al. J Vasc Res 200512 S2010-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtlen_HK
dc.relation.ispartofThe FASEB Journalen_HK
dc.titleC-Type Natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation in porcine coronary arteryen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailNg, JKF: jkfng@hkucc.hku.hken_HK
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.emailVanhoutte, PMGR: vanhoutt@hku.hken_HK
dc.identifier.authorityNg, JKF=rp00544en_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.identifier.hkuros168524en_HK
dc.identifier.hkuros147371-
dc.identifier.volume22-
dc.identifier.issuemeeting abstract suppl.-
dc.publisher.placeUnited States-
dc.identifier.issnl0892-6638-

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