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Conference Paper: HRTEM and EDX Investigation of Microstructure of Bonding Zone between Bone and Hydroxyapatite in Vivo

TitleHRTEM and EDX Investigation of Microstructure of Bonding Zone between Bone and Hydroxyapatite in Vivo
Authors
KeywordsBone
Hydroxyapatite
Interface
Microstructure
Transmission electron microscope
Issue Date2004
PublisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net
Citation
Bioceramics, v. 16, p. 165-168 How to Cite?
AbstractAn investigation of the microstructure of the bonding region between hydroxyapatite (HA) and host bone in vivo has been undertaken using high-resolution transmission electron microscope (HRTEM). The TEM observation showed that the bonding region is bone-like, but not identical to bone; and that it is nanostructured with crystallites smaller than 10 nm. A continuous structure had been established crossing the interface between HA and bone-like region at 3 months after implantation. EDX analysis showed that the bone-like zone had higher levels of calcium and phosphate than bone. In addition, there was an amorphous layer on the surface of HA particles at this stage. These findings indicate that the transformation from crystalline to amorphous HA had occurred prior to HA biodegradation, and that the mechanism of the formation of bonding zone might have involved the dissolution of amorphous HA in surrounding solution and precipitation of nanocrystalline HA in the over-saturated solution. The good mechanical properties of the bonding region can be attributable to its nanostructure, high levels of calcium and phosphate, and chemical bonding crossing the interface between the bonding-zone and HA particles.
Persistent Identifierhttp://hdl.handle.net/10722/103323
ISSN
2023 SCImago Journal Rankings: 0.172
References

 

DC FieldValueLanguage
dc.contributor.authorChen, QZen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorWong, CTen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-09-25T21:07:47Z-
dc.date.available2010-09-25T21:07:47Z-
dc.date.issued2004en_HK
dc.identifier.citationBioceramics, v. 16, p. 165-168en_HK
dc.identifier.issn1013-9826en_HK
dc.identifier.urihttp://hdl.handle.net/10722/103323-
dc.description.abstractAn investigation of the microstructure of the bonding region between hydroxyapatite (HA) and host bone in vivo has been undertaken using high-resolution transmission electron microscope (HRTEM). The TEM observation showed that the bonding region is bone-like, but not identical to bone; and that it is nanostructured with crystallites smaller than 10 nm. A continuous structure had been established crossing the interface between HA and bone-like region at 3 months after implantation. EDX analysis showed that the bone-like zone had higher levels of calcium and phosphate than bone. In addition, there was an amorphous layer on the surface of HA particles at this stage. These findings indicate that the transformation from crystalline to amorphous HA had occurred prior to HA biodegradation, and that the mechanism of the formation of bonding zone might have involved the dissolution of amorphous HA in surrounding solution and precipitation of nanocrystalline HA in the over-saturated solution. The good mechanical properties of the bonding region can be attributable to its nanostructure, high levels of calcium and phosphate, and chemical bonding crossing the interface between the bonding-zone and HA particles.en_HK
dc.languageengen_HK
dc.publisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.neten_HK
dc.relation.ispartofKey Engineering Materialsen_HK
dc.subjectBoneen_HK
dc.subjectHydroxyapatiteen_HK
dc.subjectInterfaceen_HK
dc.subjectMicrostructureen_HK
dc.subjectTransmission electron microscopeen_HK
dc.titleHRTEM and EDX Investigation of Microstructure of Bonding Zone between Bone and Hydroxyapatite in Vivoen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0346885599en_HK
dc.identifier.hkuros89184en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0346885599&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume254-256en_HK
dc.identifier.spage165en_HK
dc.identifier.epage168en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridChen, QZ=8353179600en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridWong, CT=7404954512en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.issnl1013-9826-

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