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Conference Paper: A comparison of non-TBI and TBI conditioning regimens in bone marrow recipients undergoing match-unrelated transplantation in Hong Kong
Title | A comparison of non-TBI and TBI conditioning regimens in bone marrow recipients undergoing match-unrelated transplantation in Hong Kong |
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Authors | |
Issue Date | 2000 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bbmt |
Citation | The 2000 Tandem BMT Meetings, 26 March-1 April 2000. In Biology of Blood and Marrow Transplantation, 2000, v. 6 n. 2, p. 124, abstract no. 27 How to Cite? |
Abstract | The present study investigated the effects of non-Total Body Irradiation
(TBI) conditioning on the outcome of 8 patients (CML = 5 ;
A M L = 3; Mean age 32.8 ± 3.3) undergoing Matched-Unrelated Bone
Marrow Transplantation (MUD BMT) using busulfan (16 mg/kg) and
cyclophosphamide (150 mg/kg). The outcome of 28 patients
( C M L = 16; AML = 7; Biphenotypic acute leukaemia = 2; ALL = 2 ;
M D S = 1) using TBI (12Gy) containing regimen (Mean age 29.3 ± 1.7 )
were also analyzed. The number of days requiring TPN (due to oral
mucositis) was significantly lower in the Bu-Cy group (18 ± 3.6 days)
compared with the control (31.9 ± 4.1 days, p<0.05). There were no differences
in neutrophil (ANC > 0.5 x 10 9/L) and platelet (>25 x 109/ L
without transfusion) engraftments. The Bu-Cy group had less venoocclusive
disease (VOD) (2/8 vs 11/28 in control) but more haemorrhagic
cystitis (HC) (3/8 vs 5/28 in control) though the differences were not
s i g n i ficant (p>0.05). Patients in the Bu-Cy group also had a signific a n t l y
lower occurrence (1/8) of severe GVHD (Overall grade ³2) than the
control group (18/28) (p<0.05). Transplant-related mortality (TRM)
within 100 days after BMT was 0 in the Bu-Cy group but was 7 (out of
28) in the control (GVHD related = 4; Regimen-related toxicity = 2 ;
Graft failure = 1). The difference, however, did not reach statistical sign
i ficance (p>0.05). There was no difference in the occurrence of early
graft failure in both groups of patients (1/8 in the Bu-Cy group vs 3/28
in the control). In conclusion, we have shown that the use of Bu-Cy during
conditioning in MUD BMT had no adverse effect on neutrophil and
platelet engraftments and did not increase the occurrence of graft failure.
TBI based conditioning was associated with increased severity of oral
mucositis and increased risk of VOD and severe GVHD and a higher
transplant-related mortality. |
Description | Combined annual meetings of CIBMTR and the American Society of Blood and Marrow Transplantation (ASBMT) pp. 116-161 of this journal issue entitled: Abstracts from the Annual Tandem Meetings of the American Society for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry/Autologous Blood and Marrow Transplant Registry ... 2000 |
Persistent Identifier | http://hdl.handle.net/10722/100994 |
ISSN | 2022 Impact Factor: 4.3 2020 SCImago Journal Rankings: 2.301 |
DC Field | Value | Language |
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dc.contributor.author | Lie, AKW | - |
dc.contributor.author | Leung, AYH | - |
dc.contributor.author | Liang, RHS | - |
dc.date.accessioned | 2010-09-25T19:31:42Z | - |
dc.date.available | 2010-09-25T19:31:42Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | The 2000 Tandem BMT Meetings, 26 March-1 April 2000. In Biology of Blood and Marrow Transplantation, 2000, v. 6 n. 2, p. 124, abstract no. 27 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.uri | http://hdl.handle.net/10722/100994 | - |
dc.description | Combined annual meetings of CIBMTR and the American Society of Blood and Marrow Transplantation (ASBMT) | - |
dc.description | pp. 116-161 of this journal issue entitled: Abstracts from the Annual Tandem Meetings of the American Society for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry/Autologous Blood and Marrow Transplant Registry ... 2000 | - |
dc.description.abstract | The present study investigated the effects of non-Total Body Irradiation (TBI) conditioning on the outcome of 8 patients (CML = 5 ; A M L = 3; Mean age 32.8 ± 3.3) undergoing Matched-Unrelated Bone Marrow Transplantation (MUD BMT) using busulfan (16 mg/kg) and cyclophosphamide (150 mg/kg). The outcome of 28 patients ( C M L = 16; AML = 7; Biphenotypic acute leukaemia = 2; ALL = 2 ; M D S = 1) using TBI (12Gy) containing regimen (Mean age 29.3 ± 1.7 ) were also analyzed. The number of days requiring TPN (due to oral mucositis) was significantly lower in the Bu-Cy group (18 ± 3.6 days) compared with the control (31.9 ± 4.1 days, p<0.05). There were no differences in neutrophil (ANC > 0.5 x 10 9/L) and platelet (>25 x 109/ L without transfusion) engraftments. The Bu-Cy group had less venoocclusive disease (VOD) (2/8 vs 11/28 in control) but more haemorrhagic cystitis (HC) (3/8 vs 5/28 in control) though the differences were not s i g n i ficant (p>0.05). Patients in the Bu-Cy group also had a signific a n t l y lower occurrence (1/8) of severe GVHD (Overall grade ³2) than the control group (18/28) (p<0.05). Transplant-related mortality (TRM) within 100 days after BMT was 0 in the Bu-Cy group but was 7 (out of 28) in the control (GVHD related = 4; Regimen-related toxicity = 2 ; Graft failure = 1). The difference, however, did not reach statistical sign i ficance (p>0.05). There was no difference in the occurrence of early graft failure in both groups of patients (1/8 in the Bu-Cy group vs 3/28 in the control). In conclusion, we have shown that the use of Bu-Cy during conditioning in MUD BMT had no adverse effect on neutrophil and platelet engraftments and did not increase the occurrence of graft failure. TBI based conditioning was associated with increased severity of oral mucositis and increased risk of VOD and severe GVHD and a higher transplant-related mortality. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bbmt | - |
dc.relation.ispartof | Biology of Blood and Marrow Transplantation | - |
dc.rights | Posting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.title | A comparison of non-TBI and TBI conditioning regimens in bone marrow recipients undergoing match-unrelated transplantation in Hong Kong | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lie, AKW: akwlie@hku.hk | - |
dc.identifier.email | Leung, AYH: ayhleung@hku.hk | - |
dc.identifier.email | Liang, RHS: rliang@hku.hk | - |
dc.identifier.authority | Leung, AYH=rp00265 | - |
dc.identifier.authority | Liang, RHS=rp00345 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/S1083-8791(00)70075-9 | - |
dc.identifier.hkuros | 60341 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 124, abstract no. 27 | - |
dc.identifier.epage | 124, abstract no. 27 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1083-8791 | - |