ResearcherPage View Count

Geo Map
Region#
AS - Asia22098
NA - North America13407
EU - Europe12235
AF - Africa2785
OC - Oceania1132
HKU - The University of Hong Kong679
SA - South America45
UND - Undefined891
Total53272
Country#
US - United States13289
CN - China10376
GB - United Kingdom5170
SG - Singapore3743
KR - Republic of Korea3348
IE - Ireland3343
HK - Hong Kong2313
ZA - South Africa2265
NL - Netherlands1878
JP - Japan1814
OTH - Others5733
Total53272
City#
Singapore3692
Ashburn3530
Dublin3338
Beijing3168
Johannesburg2263
Amsterdam1325
Busan1302
Tokyo1197
London1116
Sydney1073
Others31268
Total53272
A histological grading system for evaluating disc degeneration in the mouse93
SPINE-GEL: a global gene expression library for the developing nucleus pulposus27
Impact of trp2 allele mutation of α2 chain in collagen IX on the structural integrity of human annulus fibrosus78
Functionally replicated bioimprint scaffold to support tenocytic differentiation of mesenchymal stem cells55
Phylogenetic analysis of planarian collagens and their roles in regeneration38
Tissue Engineering for Intervertebral Disk Degeneration207
Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development32
Fine-tuning of notochord midline position via cell-matrix interactions57
Identifying therapeutic chemical agents for osteoarthritis by high throughput screening106
Serum metabolomic biomarkers and lumbar disc degeneration22
Development of three-dimensional culture system for bovine nucleus pulposus cells40
A rat serum glycoprotein whose synthesis rate increases greatly during inflammation110
Reconstitution Of Nucleus Pulposus Cell Matrix Niche In 3D Collagen Microsphere For MSC Discogenic Differentiation62
CELL-MATRIX MICROSPHERES, METHODS FOR PREPARATION AND APPLICATIONS120
Cell-Matrix Microspheres, Methods for Preparation and Applications128
(ii) Family-based linkage and case control association studies174
Single cell transcriptomes reveal a mesenchymal state during chondrocyte to osteoblast transition.52
Identification and characterization of long-range SOX9 enhancers in limb development154
Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo95
Trans-ethnic polygenic analysis supports genetic overlaps of lumbar disc degeneration with height, body mass index, and bone mineral density104
The influence of progenitor cells in intervertebral disc degeneration and regeneration35
Kinesin-1 is involved in chondrocytes interaction with extracellular matrix44
Genome-wide association study of adolescent idiopathic scoliosis in southern China107
In vitro generation of osteo-chondroprogenitors164
Gli-mediated regulation of Sox9 in limb development53
CELL-MATRIX MICROSPHERES, METHODS FOR PREPARATION AND APPLICATIONS92
Biochemical heterogeneity of type I collagen mutations in osteogenesis imperfecta.109
A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range271
Genetic contribution to degeneration and repair potentials of the intervertebral disc in mice68
Regeneration of nucleus pulposus after discectomy by autologous mesenchymal stem cells: A rabbit model42
Mechanisms of hereditary factors137
Chondrocytes from the endplate cartilage contribute to the inner annulus fibrosus in normal and degenerative intervertebral disc72
Molecular consequences of Indian hedgehog mutations in chick neural tube86
Epitope specificity of antibodies to type II collagen in rheumatoid arthritis and systemic lupus erythematosus182
A structural mutation of the collagen α1(I)CB7 peptide in lethal perinatal osteogenesis imperfecta158
Genome-wide association study of Degenerative Disc Disease (DDD)131
Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative11
Structural and functional evaluation of allogeneic MSC-based disc regeneration: implications of dosage and stage of degeneration with long-term follow-up107
Understanding the molecular pathogenesis of SOX9 Y440X campomelic dysplasia92
Tenogenic differentiation of human mesenchymal stem cells on novel bio-imprinted scaffolds50
Collagen studies in newborn rat kidneys with incomplete ureteric obstruction167
In vivo cellular adaptation to ER stress: Survival strategies with double-edged consequences196
Deletion of 24 amino acids from the Pro-α1(I) chain of type I procollagen in a patient with the Ehlers-Danlos syndrome type VII116
Generation of induced pluripotent stem (iPS) cells from bone-formating cells130
Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells196
Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain167
Genetic contribution to intervertebral discs integrity maintenance in mouse model51
Collagen microspheres: a three-dimensional culture system for notochordal cells125
The role of genetics in pain131
The Hong Kong Genome Wide Association Study: How should we move forward?21
Nano-scale morphology of disc collagens and their correlation with disc mechanics139
Type X collagen NC1 mutations produced by site-directed mutagenesis prevent in vitro assembly100
Implications of Gas1 in Synovial Joint Cavitation and Disease Mechanism of Brachydactyly A165
Comparison of proteomic datasets from hypertrophic chondrocytes in response to ER stress62
Aberrant signal peptide cleavage of collagen X in schmid metaphyseal chondrodysplasia. Implications for the molecular basis of the disease205
A base substitution in the exon of a collagen gene causes alternative splicing and generates a structurally abnormal polypeptide in a patient with Ehlers-Danlos Syndrome Type VII207
Osteogenic behavior of alginate encapsulated bone marrow stromal cells: An in vitro study220
Fate of growth plate hypertrophic chondrocytes: Death or lineage extension?54
Bone and Development (Book Review)116
Bioengineered intervertebral discs and methods for their preparation75
β1 integrin regulates convergent extension in mouse notogenesis, ensures notochord integrity and the morphogenesis of vertebrae and intervertebral discs28
Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice176
Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region117
Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse187
Carbon plasma immersion ion implantation of nickel-titanium shape memory alloys183
Isolation and characterization of cell subpopulation with stem cell properties in human and monkey intervertebral disc (ivd)156
A comparison of intravenous and intradiscal delivery of multipotential stem cells on the healing of injured intervertebral disk71
Investigating molecular pathogenesis of Campomelic Dysplasia57
Can stem cells home to the injured intervertebral disc via intravenous infusion? A murine model51
Identification and characterization of long-range SOX9 enhancers in limb development42
The effect of severity of disc degeneration on mesenchymal stem cells' ability to regenerate the intervertebral disc: a rabbit model44
Osteogenic differentiation of alginate microencapsulated mesenchymal stem cells for bone formation: An in vitro study162
Reply39
Etiology of developmental spinal stenosis: A genome‐wide association study145
Lethal perinatal osteogenesis imperfecta due to the substitution of arginine for glycine at residue 391 of the α1(I) chain of type I collagen143
Cells in the endplate cartilage contribute to the inner annulus fibrosus in the intervertebral disc177
Differentiation and migration of endplate chondrocytes contribute to the inner annulus fibrosus in normal and degenerative intervertebral disc29
Linkage analysis with subsequent fine-mapping on familial early onset-degenerative disc disease.116
The genetics of intervertebral disc degeneration117
Protein and gene expression profiles of the intervertebral disc: in health and disease106
Collagen-mesenchymal stem cell microspheres for cartilage tissue engineering125
Differentiation and progression of interzone cells as progenitors of articular chondrocytes in joint formaiton63
How has genetics research altered our understanding of degenerative disc disease: Implications for intervertebral disc regeneration134
Enhanced corrosion resistance and biocompatibility by plasma implantation of nickel titanium alloys: an in vitro and surface chemical study126
Single cell analyses of human intervertebral discs implicate HOPX as a regulator of homeostasis67
Decellularization of chondrocyte-encapsulated collagen microspheres: A three-dimensional model to study the effects of acellular matrix on stem cell fate183
Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2308
An α1(II) Gly913 to Cys substitution prevents the matrix incorporation of type II collagen which is replaced with type I and III collagens in cartilage from a patient with hypochondrogenesis152
Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth58
Hypertrophic Chondrocytes Can Become Osteoblasts and Osteocytes in Endochondral Bone Formation90
Presence of notochord descendent cells in the nucleus pulposus of adult mice showing signs of intervertebral disc degeneration115
Mesenchymal stem cells based osteochondral tissue engineering40
(iii) Whole-genome association studies of complex diseases137
Kinesin-1 is involved in chondrocytes adhesion to extracellular matrix and motility40
Identification of novel serum metabolomic biomarkers related to the development of lumbar disc degeneration48
Role of IHH signaling in the progression of joint formation in digit development89
Linkage analysis on familial early onset degenerative disc disease118
Integration of factors and pathways facilitating chondrocyte adaptation to ER stress117
Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels249
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region252
Dosage-dependent requirement of sedlin component of the TRAPP complex in mouse embryonic development59
Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress pathway for survival39
Mechanical properties, bioactivity and corrosion resistance of oxygen and sodium plasma treated nickel titanium shape memory alloy187
Role of type II collagen turnover in disc development and degeneration146
Role of Pax1 in the homeostasis of the spine and pathogenesis of Adolescent Idiopathic Scoliosis57
New plasma surface-treated memory alloys: Towards a new generation of "smart" orthopaedic materials162
The Role of Matrix Turnover on Differentiation of Intervertebral Disk Cells46
Generation of an osteochondral interface using rabbit mesenchymal stem cells (rMSCS) and collagen gel89
Towards understanding genetic and molecular etiology of campomelic dysplasia32
A type III collagen Gly559 to arg helix mutation in Ehler's danlos syndrome type IV115
Substitution of arginine for glycine 664 in the collagen α1(I) chain in lethal perinatal osteogenesis imperfecta. Demonstration of the peptide defect by in vitro expression of the mutant cDNA165
BIOENGINEERED INTERVERTEBRAL DISCS AND METHODS FOR THEIR PREPARATION154
Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians275
Bioinformatics-aided discovery of transcriptional regulators of chondrocyte differentiation in the growth plate60
Impact Of Activating Adamts-5 In Cartilage-related Degenerative Disorders88
Molecular and developmental insights into the pathogenesis of the SOX9Y440X campomelic dysplasia mutation111
Marfan syndrome: Absence of type I or III collagen structural defects in 25 patients186
The potential of umbilical cord derived mesenchymal stem cells in intervertebral disc repair48
Kinesin-1 is necessary for cytokinesis in chondrocytes30
Hypertrophic chondrocytes contribute directly to the osteoblast and osteocyte lineage in endochondral bones in vivo74
Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis213
Regulation of procollagen synthesis and processing during ascorbate-induced extracellular matrix accumulation in vitro119
Linkage analysis on familial early-onset degenerative disc disease(DDD)127
COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid235
Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair101
Detection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy77
Modulating proteoglycan metabolism using small molecules as treatment for disc degeneratioin93
Nucleic acid aptamers against ADAMTS as a new therapeutic approach against degenerative disc disease110
Collagen-mesenchymal stem cell microspheres for the repair of articular cartilage defects in a rabbit model.52
Reconstitution of nucleus pulposus cell matrix niche in 3D collagen microsphere for mesenchymal stem cell discogenic differentiation47
Loss of β-catenin in hypertrophic chondrocytes results in abnormal bone formation126
Peptide analysis of collagen produced from cDNA by transcription and translation in vitro.146
Development of 3D system for culturing notochordal cells86
Genetic and genomic analyses of chondrocyte adaptation to ER stress132
Decellularization of chondrocyte-encapsulated collagen microspheres: a 3D model to study effects of acellular matrix on stem cell fate94
Genetic susceptibility of intervertebral disc degeneration among young Finnish adults194
Mannose binding lectin and autoimmune disease103
Molecular and cellular consequences of Indian hedgehog mutations causing brachydactylies42
sPDZD2: a novel negative modulator of hedgehog signaling29
Sedlin and prostaglandin E2 dehydrogenase - interactions and implications for spondyloepiphyseal dysplasia tarda82
Molecular and mutation analysis of hereditary multiple exostoses129
Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study59
In-Vivo Study of Asporin in Cartilage Tissues105
Extracellular matrix in planarian regeneration and stem cell maintenance58
Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration2
Epigenetic reprogramming of fibroblasts into osteo-chondroprogenitors122
Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in Southern Chinese167
Mechanisms of chondrocyte adaptation and survival under ER stress84
Genome-wide association study of adolescent idiopathic scoliosis in southern Chinese110
Differential functions of cyclooxygenase 1 and 2 in bone repair119
Cryopreserved intervertebral disc with injected bone marrow-derived stromal cells: a feasibility study using organ culture141
A 5' splice site mutation affecting the pre-mRNA splicing of two upstream exons in the collagen COL1A1 gene. Exon 8 skipping and altered definition of exon 7 generates truncated proα1(I) chains with a non-collagenous insertion destabilizing the triple helix189
Cadherin 2/N-cadherin regulates notochordal cell function and intervertebral disc homeostasis56
The chondrocytic journey in endochondral bone growth and skeletal dysplasia58
Sox9 mediates gene expression specificity in growth plate chondrocytes via concomitant positive and negative regulation118
The role of hypertrophic chondrocyte and cellular stress in intervertebral disc integrity and degeneration29
An externally fixed femoral fracture model for mice190
Identification and characterization of long-range SOX9 enhancers in limb development48
Collagen II is essential for the removal of the notochord and the formation of intervertebral discs192
Both HIF-1α and HIF-2α are present in prenatal and postnatal nucleus pulposus cells52
Genetic control of chondrocyte adaptation to ER stress in chondrodysplasia49
Association of the asporin D14 allele with lumbar disc degeneration157
Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function.215
Formation of CAPO4 and Suppression of Ni Leaching in Nitinol Using Oxygen and Sodium Plasma Immersion Ion Implantation173
Descendents of LGR5-expressing interzone cells are localized to the superficial layer of the articular cartilage60
Cholesterol biosynthesis is a potential pathway involved in the degeneration of the annulus fibrosus99
Integration of factors and pathways facilitating chondrocyte adaptation to ER stress29
Roles of progenitor cells for intervertebral disc regeneration in "healer" mice28
A frameshift mutation results in a truncated nonfunctional carboxyl-terminal Proα1(I) propeptide of type I collagen in osteogenesis imperfecta165
The PERK pathway attenuates ER stress in hypertrophic chondrocytes via SOX9 and FGF2133
Three-dimensional culture of bovine nucleus pulposus cells in protein matrices61
Genes and Diseases: Basic Concepts138
The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study75
The role of autophagy in determining chondrocyte cell fates in response to ER stress107
Missense mutations in IHH impair Indian hedgehog signaling in C3H10T1/2 cells: Implications for brachydactyly type A1, and new targets for hedgehog signaling196
In vitro and in vivo characterization of novel plasma treated nickel titanium shape memory alloy for orthopedic implantation199
Genome-wide association study of Degenerative Disc Disease (DDD)166
A splicing mutation in the ext2 gene affects messenger RNA stability in a family with hereditary multiple exostoses127
Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population162
Extracellular matrix and stem cell niche in the regenerating planarian66
Mesenchymal stem cell-collagen microspheres for articular cartilage repair: cell density and differentiation status.62
Collagen-mesenchymal stem cell microspheres for cartilage tissue engineering160
Cadherin 2 as human notochordal cell marker and its expression pattern in disc degeneration84
The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress48
Decellularization of chondrocyte-encapsulated collagen microspheres: a 3D model to study effects of acellular matrix on stem cell fate120
An effective dose of valdecoxib in experimental mouse models of pain161
Time-lapse imaging of planarian regeneration37
Phenotypic and biochemical consequences of collagen X mutations in mice and humans145
Cell-matrix microspheres, methods for preparation and applications100
Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage regeneration50
Generation of mouse notochord cell lines for the study of notochord function during intervertebral disc development158
Molecular basis for growth plate abnormalities in a mouse model with schmid metaphyseal chondrodyplasia115
A base substitution at a splice site in the COL3A1 gene causes exon skipping and generates abnormal type III procollagen in a patient with Ehlers-Danlos syndrome type IV173
Extracellular matrix and the stem cell niche in the regenerating planarian100
Mutations in COMP cause familial carpal tunnel syndrome41
Label-free quantitative proteomics reveals survival mechanisms developed by hypertrophic chondrocytes under ER stress128
Gelatinase A (MMP-2) activation by skin fibroblasts: dependence on MT1-MMP expression and fibrillar collagen form120
Role of IHH signaling in the progression of joint formation in digit development87
Identification of therapeutic agents for the treatment of osteoarthritis with the application of high-throughput screening106
In vivo chondrocytic differentiation of the allogenic stem cells in the murine intervertebral disc159
Correlation between the nano-structure and the macro-mechanics of the human intervertebral discs107
Culture of chondrocytes of hereditary multiple exostosis in vitro125
Dual origin of osteoblasts in bone formation: terminally differentiated chondrocytes contribute to bone formation in vivo94
Changes in collagen stability and folding in lethal perinatal osteogenesis imperfecta. The effect of α1(I)-chain glycine-to-arginine substitutions243
Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals259
Mechanistic insight into chondrocyte adaptation to ER stress111
A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas.201
Use of tandem mass spectrometry as a tool for proteomics studies in aging and degeneration processes of the intervertebral disc136
Site-directed mutagenesis of human type X collagen. Expression of α1(X) NC1, NC2, and helical mutations in vitro and in transfected cells107
Collagen X deficiency exacerbates pathological calcification and impairs carilage remodeling in MGP-null mice56
(iv) Genetics of disc degeneration183
Repair of osteochondral defects with collagen-mesenchymal stem cell microspheres in a rabbit model106
Bone Pathology125
Lack of β1 integrin in the developing mouse notochord results in hemivertebrae115
Hypertrophic chondrocytes survive ER stress by maintaining glycolysis and mitochondrial membrane poloarity34
Investigation of nickel suppression and cytocompatibility of surface-treated nickel-titanium shape memory alloys by using plasma immersion ion implantation183
MT1-MMP-dependent and -independent regulation of gelatinase A activation in long-term, ascorbate-treated fibroblast cultures: Regulation by fibrillar collagen116
The molecular and cellular changes underlying increased bone formation in a mouse model with generalized progressive hyperostosis24
Target Identification of a novel small molecule for treating joint degeneration13
Genetic association studies in lumbar disc degeneration: a systematic review51
Corrosion resistance, surface mechanical properties, and cytocompatibility of plasma immersion ion implantation-treated nickel-titanium shape memory alloys166
Comprehensive Analysis of MRI‐phenotypes Provides New Insights into Lumbar Disc Degeneration for Genetic Studies94
Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction173
Identification Of Small Molecule For Treating Intervertebral Disc Degeneration Via Interfering Proteoglycans Catabolic Degradation27
Insights into the cellular basis of intervertebral disc disease gained from the transcriptomes of single cells62
Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia165
Proteomics analysis of the human intervertebral disc reveals potential fibrotic events in degeneration36
Collagen defects in lethal perinatal osteogenesis imperfecta158
The Role of β‑catenin-IRX3/5 Regulatory Network in Hypertrophic Chondrocyte Descendant Cell Fate21
The role of hypertrophic chondrocytes and cellular stress in intervertebral disc integrity and degeneration27
Comprehensive Analysis of MRI-Phenotypes Provides New Insights into Lumbar Disc Degeneration for Genetic Studies87
Nanostiffness of Collagen Fibrils Extracted From Osteoarthritic Cartilage Characterized with AFM Nanoindentation77
Induction of osteo-chondroprogenitors formation during transcription factor-mediated reporgramming process52
Are There Protective Genes for Disc Degeneration?57
Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors148
Kinesin-1 is necessary for cytokinesis in chondrocytes140
iCartiGD: The Integrated Cartilage Gene Database126
Intervertebral disc cell biosynthesis in the degenerate and non-degenerate intervertebral disc28
Bioengineered Intervertebral Discs and Methods for Their Preparation130
Fine mapping candidate loci for nasopharyngeal carcinoma (NPC) in southern Chinese specifically linked to EBV aetiopathogenesis116
Sequential expression of Lgr5 and Col22a1 in developing synovial joints marks the progressive differentiation of progenitor cells to articular chondrocytes41
Uncovering small chemical molecules for treatment of intervertebral disc degeneration74
In vivo study of Asporin, a genetic risk factor for osteoarthritis and degenerative disc disease92
Quantitation of type I and III collagens using electrophoresis of alpha chains and cyanogen bromide peptides145
Defining the phenotype and molecular signatures of notochordal nucleus pulposus cells118
Matrix remodeling during intervertebral disc growth and degeneration detected by multichromatic fast staining251
Type X collagen multimer assembly in vitro is prevented by a Gly618 to Val mutation in the α1(X) NC1 domain resulting in Schmid metaphyseal chondrodysplasia175
Characterization of three osteogenesis imperfecta collagen α1(I) glycine to serine mutations demonstrating a position-dependent gradient of phenotypic severity136
Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs25
Small Molecule Inhibitors Of Interleukin-1 Mediated Proteoglycan Catabolism In Joint Degeneration24
Coming together is a beginning: The making of an intervertebral disc124
Role of cadherin 2 in intervertebral disc homeostasis36
Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events100
Transcriptome of the human intervertebral disc in health and disease116
In vivo study of asporin, a genetic risk factor for osteoarthritis and degenerative disc disease88
Generation of induced pluripotent stem (iPS) cells from bone forming cells40
Type IIA Procollagen as a Modulator of Nodal Signaling39
Enrichment of committed human nucleus pulposus cells expressing chondroitin sulfate proteoglycans under alginate encapsulation73
Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions67
Minimizing cryopreservation-induced loss of disc cell activity for storage of whole intervertebral discs183
Candidate gene study of polymorphisms of interleukin-1 in lumbar disc degeneration151
Roles of kinesin-1 mediated intracellular transport in skeletal development152
Analysis of the heterogeneity of human collagens by two-dimensional polyacrylamide-gel electrophoresis170
Separation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy137
CELL-MATRIX MICROSPHERES, METHODS FOR PREPARATION AND APPLICATIONS139
Genetic association studies in lumbar disc degeneration: a systematic review48
Dosage-dependent requirement of Sedlin and Sedlin-like proteins in mouse yolk-sac visceral endoderm and embryo development37
Integration of pathways mediating chondrocyte adaptation to ER stress in VIVO95
Nitrogen plasma-implanted nickel titanium alloys for orthopedic use202
Mesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic events56
Fate and properties of notochordal descendent cells in the intervertebral disc: implication to disc degeneration55
Effect of impaired matrix turnover on differentiation of intervertebral disc cells34
Genetic association studies in lumbar disc degeneration: a systematic review71
A role of biglycan C-terminal peptide in regulating intervertebral disc homeostasis24
Interleukin-1 beta (IL-1β) and osteoprotegrin (OPG) gene polymorphisms are associated with knee osteoarthritis in Chinese25
Role of Pax1 in the etiology of adolescent idiopathic scoliosis34
Generation of induced pluripotent stem (iPS) cells from bone-forming cells122
New plasma surface treated memory alloys: Towards a new generation of "smart" orthopaedic materials134
Three dimensional culture and chondrogenic differentiation of mouse embryonic stem cells79
Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study54
Abnormal type I collagen metabolism by cultured fibroblasts in lethal perinatal osteogenesis imperfecta169
FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress58
Coupling of small leucine-rich proteoglycans to hypoxic survival of a progenitor cell-like subpopulation in Rhesus Macaque intervertebral disc91
Development of Three-Dimensional Culture System for Maintenance of Bovine Nucleus Pulposus Cells75
Developmental Origins of Osteoblasts in Endochondral Bone Formation82
Investigating impact of Sox9 dysfunction in hypertrophic chondrocytes-to-osteoblasts transition.26
Identification Of Small Molecule For Treating Intervertebral Disc Degeneration Via Interfering Proteoglycans Catabolic Degradation25
Molecular and developmental insights into the pathogenesis of the SOX9Y440X campomelic dysplasia mutation151
Collagen composition of normal and myxomatous human mitral heart valves160
Expression of the Trp2 allele of COL9A2 is associated with alterations in the mechanical properties of human intervertebral discs148
Burden of rare variants in ALS genes influences survival in familial and sporadic ALS147
Identification and characterization of long-range SOX9 enhancers in limb development41
Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc60
An essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus198
Epigenetic reprogramming of fibroblasts into osteo-chondroprogenitors122
In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute183
Generation of induced pluripotent stem (iPS) cells from bone-forming cells119
Kinesin-1 is necessary for chondrocyte cytokinesis173
SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese240
The association of disc degeneration based on magnetic resonance imaging and the presence of low back pain95
Effects of nucleus pulposus cell-derived acellular matrix on the differentiation of mesenchymal stem cells83
Lineage extension chondrocytes and the ontogeny of bone cells109
sPDZD2, a novel modulator in Hedgehog signaling81
Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI162
PRIMUS: Comprehensive proteomics of mouse intervertebral discs that inform novel biology and relevance to human disease modelling31
Characterization of a type I collagen α2(I) glycine-586 to valine substitution in osteogenesis imperfecta type IV. Detection of the mutation and prenatal diagnosis by a chemical cleavage method117
Roles of Progenitor Cells for Intervertebral Disc Regeneration in 'Healer' Mice94
Extracellular matrix and stem cell niche in the regenerating planarian146
Development of protein-based 3D culture system for bovine nucleus pulposus cells23
Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis81
In vivo study of asporin polymorphic variants in chondrogenesis and degenerative skeletal diseases124
Screening small molecule ihibitors against proteoglycan degradation to control tissue degeneration63
Three genes in the aggrecan degradation pathway act synergistically to predispose to degenerative disc disease158
Genetic Basis of Intervertebral Disc Degeneration137
Degradome of the Intervertebral Disc65
Characterization of molecular and cellular consequences in OI type V osteoblasts36
Structure and Biology of the Intervertebral Disk in Health and Disease152
Type IIA procollagen: A positive regulator of nodal signaling during embryogenesis100
Enrichment of committed, chondroitin sulfate-expressing human nucleus pulposus cells over progenitors under alginate encapsulation40
Role of autophagy in chondrocyte differentiation21
Different mutations in sedlin cause X-linked spondyloepiphyseal dysplasia tarda via two distinct mechanisms: protein misfolding and protein-protein interaction Abrogation52
The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress141
How Has Genetics Changed Our Understanding of Disc Degeneration?143
Compression-induced alignment and elongation of human mesenchymal stem cell (hMSC) in 3D collagen constructs is collagen concentration dependent71
Cadherin 2 is required for intervertebral disc homeostasis and maintenance of vacuolated phenotype in nucleus pulposus cells87
Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice105
Effects of reconstituted collagen matrix on fates of mouse embryonic stem cells before and after induction for chondrogenic differentiation135
Efficient and seamless DNA recombineering using a thymidylate synthase A selection system in Escherichia coli120
Molecular consequences of Indian hedgehog mutations causing brachydactylies117
Alleviating ER stress in chondrocytes: survival strategies with double-edged developmental consequences117
A Systematic and Simple Scoring System for Histological Analysis of the Mouse Intervertebral Disc during Natural Ageing, Degeneration, and Regeneration60
Nanostructure of collagen fibrils in human nucleus pulposus and its correlation with macroscale tissue mechanics232
Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells138
The role of autophagy in ER-stress induced chondrocyte re-differentiation92
Enhancement of Surface Anti-Corrosion, Mechanical, and Biological Properties of Orthopedic Nickel-Titanium Shape Memory Alloys Using Carbon Plasma Immersion Ion Implantation and Deposition120
Analysis of the Static Protein Profile of Degenerated IVD Indicate Increased Fibrosis-Related Proteins83
Mesenchymal stem cells mediate disk regeneration by suppression of fibrosis in nucleus pulposus210
First meeting in Asia of the Asia Pacific Research Integrity network38
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.154
Reconstructing the chondro-osteoblastic lineage by single cell RNA-seq122
A novel pathway associated with lumbar disc degeneration: a genome-wide association study82
A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice169
PDZD2, a candidate gene for brachdactyly type A1, encodes a secreted protein that negatively modulates hedgehog signalling32
The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration143
Impact of intracellular clearance of unfolded proteins on chondrocytes cell fate93
sPDZD2, a novel modulator in Hedgehog signaling104
Oxygen and sodium plasma-implanted nickel-titanium shape memory alloy: a novel method to promote hydroxyapatite formation and suppress nickel leaching166
Biochemical consequences of sedlin mutations that cause spondyloepiphyseal dysplasia tarda147
Principles of Developmental Genetics170
Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders55
Induction of osteo-chondroprogenitors formation during transcription factor-mediated reprogramming processes38
Uncoupled endochondral ossification in transgenic mice expressing type X collagen with mutations in the NC1 domain121
Genetic and genomic analyses of chondrocyte adaptation to ER stress in vivo133
Development Of Three-Dimensional System For Culturing Notochordal Cells47
Kinesin-1 is necessary for cytokinesis in chondrocytes151
PDZD2, a candidate gene for brachydactyly type A1, encodes a secreted protein that negatively modulates hedgehog signaling29
DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics27
Wnt-beta-Catenin Controls The Chondrocyte To Osteoblast Lineage Transition In Endochondral Bone Formation26
Association between promoter - 1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese187
Collagen IV differentially regulates planarian stem cell potency and lineage progression24
Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration105
Mechanistic insights into skeletal development gained from genetic disorders63
How Reliable Are the Reported Genetic Associations in Disc Degeneration?140
Two-dimensional assays of peptide fragments107
Rapid fractionation of collagen chains and peptides by high-performance liquid chromatography159
The molecular and cellular basis of exostosis formation in hereditary multiple exostoses200
Type IIA procollagen: a positive regulator of nodal signaling during early embryogenesis35
Type IIA Procollagen: A Positive Regulator of Nodal Signaling During Early Vertebrate Embryogenesis102
Understanding the molecular mechanisms of skeletal dysplasia through proteomics of mutant collagen X protein-expressing chondrocytes97
The role of extracellular matrix in planarian regeneration24
A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in cartilage132
Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease382
Nickel suppression in Ni-Ti alloys by plasma immersion ion implantation surface treatment: New materials for orthopaedic implantation162
Postnatal Expression of Pax1 in the Intervertebral Disc during Postnatal Growth and Response to Spinal Curvature52
Generation of a mouse model to study ADAMTS-5 as a genetic risk factor for intervertebral disc degeneration83
The study of extracellular matrix and stem cell niche in planarian135
In vivo study of asporin, a genetic risk factor for intervertebral disc degeneration134
Kinesin-1 is involved in chondrocytes adhesion to extracellular matrix and motility54
Multiexon deletions in the type I collagen COL1A2 gene in osteogenesis imperfecta type IB. Molecules containing the shortened α2(I) chains show differential incorporation into the bone and skin extracellular matrix106
Understanding the contribution of Lgr5+ interzone progenitor cells in joint repair41
Identifying therapeutic chemical agents for intervertebral disc degeneration by high throughput screening99
Integrative analysis of metabolomic, genomic, and imaging-based phenotypes identify very-low-density lipoprotein as a potential risk factor for lumbar Modic changes15
The influence of progenitor cells in intervertebral disc degeneration and regeneration39
NOA1 is an essential GTPase required for mitochondrial protein synthesis215
A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups169
Hypertrophic chondrocytes become osteoblasts and osteocytes contributing to endochondral bone formation64
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica51
A3.5 Molecular pathogenesis of SEDT: the role of sedlin and its cytoplasmic function110
Prevalence of intervertebral disc degeneration in Hong Kong-a magnetic resonance imaging study of 977 volunteers150
Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse91
Prediction of lumbar spinal stenosis in Chinese: findings from a genome-wide association study40
Ectopic expression of unfolded mutant collagen X in bone cells results in generalised hyperostosis in mice84
Matrix remodeling during intervertebral disc growth and degeneration detected by multichromatic FAST staining (Journal of Histochemistry and Cytochemistry (2009) 57, (3), (249-256))158
Interplay between ER stress and hypoxia pathways in chondrocytes172
Genome-wide association study of Degenerative Disc Disease (DDD)178
Suppression of nickel release in nickeltitanium alloys by plasma immersion ion implantation surface treatment: towards a new generation of "smart" orthopaedic implants137
Identifying small molecules for regulating proteoglycan metabolism in cartilaginous tissues30
The role of cyclooxygenase 1 and 2 in fracture repair - implications for atrophic nonunion112
Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia111
Roles of Kinesin-1 mediated intracellular transport in skeletal development38
Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells145
Regulation and Role of Transcription Factors in Osteogenesis12
Nucleus pulposus cell vacuolation: a new perspective From N-Cadherin/Cadherin 2 function39
Genome-wide association study of Degenerative Disc Disease (DDD)160
Surface mechanical properties, corrosion resistance, and cytocompatibility of nitrogen plasma-implanted nickel-titanium alloys: A comparative study with commonly used medical grade materials198
Understanding the Basis of Genetic Studies: Adolescent Idiopathic Scoliosis as an Example75
Rabbit articular cartilage repair using collagen-mesenchymal stem cell microspheres74
Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration159
Detection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy (DW-MRS)43
Phenotypic and population differences in the association between CILP and lumbar disc disease165
Nano-structure of collagen fibrils in human intervertebral discs and its correlation with the tissue mechanics176
IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis32
Mechanisms Underlying Chondrocyte Reprogramming Surviving ER Stress85
Coping With Stress in Hypertrophic Chondrocytes: The Role of PERK Pathway178
Spatiotemporal expression of cadherin 2 in the notochordal nucleus pulposus during development and aging of murine intervertebral disc117
DNA aptamers can discriminate between closely related aggrecanase drug targets for degenerative disc disease therapy34
Two subtypes of intervertebral disc degeneration distinguished by large-scale population-based study86
Role of p53/p63 in chondrocyte re-differentiation upon activation of ER stress110
Lethal perinatal osteogenesis imperfecta due to a type I collagen α2(I) gly to arg substitution detected by chemical cleavage of an mRNA:cDNA sequence mismatch153
Impact of activating ADAMTS-5 in cartilage-related degenerative disorders114
Collagen XXII interacts with integrins via new motifs and links tenocytes to myocytes107
Expression of the TRP2 allele of COL9A2 leads to alterations in the mechanical properties of human intervertebral discs115
Association of lumbar disc degeneration with type IX collagen polymorphism in Chinese150
A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration28
Phylogenetic analysis of planarian collagens and their roles in regeneration29
Abnormal chondrocyte differentiation is dosage-dependent in transgenic mice expressing unassembled mutant collagen X in hypertrophic chondrocytes135
Genetics of disc degeneration153
Role of fibrogenesis in control of disc degeneration57
Correlation between the nano-structure and macro-mechanics of human nucleus pulposus159
Chondrocytes from the endplate cartilage contribute to the inner annulus fibrosus in normal and degenerative intervertebral disc34
In vitro expression analysis of collagen biosynthesis and assembly190
Loss of β-catenin in hypertrophic chondrocytes affects trabecular bone formation26
In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: Influence of cell seeding density and collagen concentration197
Endoplasmic reticulum-mediated quality control of type I collagen production by cells from osteogenesis imperfecta patients with mutations in the proα1(I) chain carboxyl-terminal propeptide which impair subunit assembly173
Functional replication of the tendon tissue microenvironment by a bioimprinted substrate and the support of tenocytic differentiation of mesenchymal stem cells196
Recurrent substitutions of arginine 789 by cysteine in pro-α1 (II) collagen chains produce spondyloepiphyseal dysplasia congenita112
Roles of progenitors cells for intervertebral disc regeneration in "Healer" mice26
Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress signals for survival36
Investigation of the homing ability of mesenchymal-like stem cells to sites of injury using a mouse model of IVD degeneration118
Disrupted growth plates and progressive deformities in osteogenesis imperfecta as a result of the substitution of glycine 585 by valine in the α2(I) chain of type I collagen145
The PERK pathway attenuates ER stress in hypertrophic chondrocyte via Sox9 and FGF2139
Small-molecule suppressors of proteoglycan catabolism in degenerative disc cells53
Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice59
Correlation of clinical and molecular biological abnormalities in osteogenesis imperfecta.177
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc111
The role of Prkci in the development of notochord103
Comparison of annulus fibrosus cell collagen remodeling rates in a microtissue system14
Global gene expression changes during chondrocyte adaptation to ER stress133
Peptide Location Fingerprinting Reveals Tissue Region-Specific Differences in Protein Structures in an Ageing Human Organ16
Intervening intervertebral disc degeneration by small molecules that positively modulate proteoglycan production41
BIOENGINEERED INTERVERTEBRAL DISCS AND METHODS FOR THEIR PREPARATION121
Long term cytocompatibility and in vivo investigation of nitrogen plasma implanted shape memory alloy128
Genetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors139
Stem cell response to biomechanical changes in planarian regeneration34
Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis61
In vivo study of asporin, a genetic risk factor for intervertebral disc degeneration102
Genome-wide association study of adolescent idiopathic scoliosis in southern Chinese141
Basement membrane regulates adult pluripotent stem cell fates in planarian27
Induction of osteo-chondroprogenitor formation by defined transcription factor-mediated reprogramming process54
Protein and gene expression profiles of the intervertebral disc: in health and disease107
Developing three dimensional culture system for Notochordal cells65
Lack of beta1 integrin results in hemivertebrae development in mice113
Comprehensive analysis of collagen metabolism in vitro using [43H]/[14C]proline dual-labeling and polyacrylamide gel electrophoresis156
The association of osteoprotegerin gene polymorphism with knee osteoarthritis in Chinese population142
The developmental roles of the extracellular matrix: Beyond structure to regulation199
Authors' Reply147
Genetics in the understanding of disc degeneration16
Intervertebral disc cryopreservation161
Misfolding of collagen X chains harboring schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response137
Osteoprotegerin (OPG) and interleukin-1 beta (il-1b) gene polymorphisms are associated with knee osteoarthritis in Chinese135
Interaction of collagen α1(X) containing engineered NC1 mutations with normal α1(X) in vitro. Implications for the molecular basis of Schmid metaphyseal chondrodysplasia149
Lgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes70
Disc cell responses to the local environment of degenerated and non-degenerated intervertebral disc tissue32
Intervertebral disc degeneration on MRI is associated with low back pain: a population-based study89
Development of three-dimesional system for culturing notochordal cells60
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression277
Role of IHH signaling in the progression of digit joint formation158
Induction of osteo-chondroprogenitors formation by transcription-factor mediated reprogramming process41
Vertebroplasty by use of a strontium-containing bioactive bone cement232
Fabrication of an osteochondral construct with an intact interface using rabbit mesenchymal stem cells (rMSCs) and collagen gel105
Interplay between ER stress and hypoxia pathways in chondrocytes49
Phylogenetic analysis of planarian collagens and their roles in regeneration29
Characterization of an arginine 789 to cysteine substitution in α1 (II) collagen chains of a patient with spondyloepiphyseal dysplasia135
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation134
Impact of activating ADAMTS-5 in cartilage-related degenerative disorders107
Molecular consequences of Indian Hedgehog mutations causing brachydactylies in chick neural tube107
Changes in the proteome of the human intervertebral disc in aging and degeneration55
Histological and reference system for the analysis of mouse intervertebral disc116
Generation of induced pluripotent stem (iPS) cells from bone forming cells110
Mesenchymal stem cell-based repair of articular cartilage with polyglycolic acid-hydroxyapatite biphasic scaffold158
Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage development and regeneration138
In vivo study of Asporin, a genetic risk factor associated with degenerative disc diseases103
KIF5B modulates central spindle organization in late-stage cytokinesis in chondrocytes62
Low basal transcription of genes for tissue-specific collagens by fibroblasts and lymphoblastoid cells: Application to the characterization of a glycine 997 to serine substitution in α1(II) collagen chains of a patient with spondyloepiphyseal dysplasia151
Association and functional analysis of ADAMTSS in lumbar disc degeneration70
Functional roles for Irx3 and Irx5 in the hypertrophic chondrocyte to osteoblast lineage programme38
Fate and properties of notochordal descendent cells in the intervertebral disc: implicationto disc degeneration160
Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus88
Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease306


TotJulAugSepOctNovDecJanFebMarAprMayJun
2017/20185438492438310512285983218244641520481314
2018/201995157733414211997471094781100348980417851078
2019/20208005139075026760639963111901228276275516477
2020/202122916533872361850585341910703651622691908146568
2021/2022648010734213612701843102944720923064516557
2022/202391819117012743000000000
Ever53272