Regulation of [alpha]-fetoprotein gene expression in differentiating and cancer cells
Grant Data
Project Title
Regulation of [alpha]-fetoprotein gene expression in differentiating and cancer cells
Principal Investigator
Professor Chiu, Jen-fu
(Principal Investigator)
Duration
52
Start Date
2002-09-01
Amount
2018512
Conference Title
Regulation of [alpha]-fetoprotein gene expression in differentiating and cancer cells
Presentation Title
Keywords
cancer, fetoprotein, genes
Discipline
Genetic Disease
HKU Project Code
HKU 7218/02M
Grant Type
General Research Fund (GRF)
Funding Year
2002
Status
Completed
Objectives
The project attempts to: (1) Identify and characterize DAS-binding protein (DAP) that regulate [alpha]-fetoprotein expression; (2) Investigate the specific DNA binding activity and biological function of DAP. The biological function will be determined by using various mutant genes, DAP antisense sequence and transcription factor decoys; (3) Identify other genes that are regulated by the DAS cis-element through a computer-assisted analysis of the genomic sequences in GenBank; and (4) Investigate the expression of these candidate genes in F9 cells during differentiation, and in developing liver cells and hepatomas.
All Publications
| Title | Author(s) | Issue Date | Views | |
|---|---|---|---|---|
| 2008 |