Development of broad-spectrum antiviral therapy to prepare for the next pandemic: the therapeutic potential of anti-Notch synergistic regimen against respiratory viral infections
Grant Data
Project Title
Development of broad-spectrum antiviral therapy to prepare for the next pandemic: the therapeutic potential of anti-Notch synergistic regimen against respiratory viral infections
Principal Investigator
Dr Shuai, Huiping Vivian
(Principal Investigator (PI))
Duration
24
Start Date
2025-03-01
Amount
1079500
Conference Title
Development of broad-spectrum antiviral therapy to prepare for the next pandemic: the therapeutic potential of anti-Notch synergistic regimen against respiratory viral infections
Keywords
next generation antiviral, broad-spectrum antiviral, Notch signaling, respiratory viral
infection, influenza virus
Discipline
Microbiology
HKU Project Code
09230247
Grant Type
HMRF Research Fellowship Scheme 2023
Funding Year
2023
Status
On-going
Objectives
A beneficial role of Notch inhibition was recently implicated against SARS-CoV-2 infection. The antiviral mechanism is suggested to act through modulating the expression of furin, which is an essential host protease required for the infection and transmission of many respiratory tract viruses. H