Pilot study to investigate clinical impact of epigenomic molecular subtypes in nasopharyngeal carcinoma

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Grant Data
Project Title
Pilot study to investigate clinical impact of epigenomic molecular subtypes in nasopharyngeal carcinoma
Principal Investigator
Professor Dai, Wei   (Principal Investigator (PI))
Co-Investigator(s)
Dr Chow Ka Yue Larry   (Co-Investigator)
Professor Lee Victor Ho Fun   (Co-Investigator)
Duration
24
Start Date
2024-10-01
Amount
499120
Conference Title
Pilot study to investigate clinical impact of epigenomic molecular subtypes in nasopharyngeal carcinoma
Keywords
Nasopharyngeal, Prognostic biomarker, DNA methylation assay, Molecular subtyping, Targeted bisulfite
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
11222136
Grant Type
Health and Medical Research Fund 2022
Funding Year
2022
Status
On-going
Objectives
Treatment and detection for metastatic and local recurrence of nasopharyngeal carcinoma (NPC) remain clinically challenging. We previously identified two epigenomic subtypes of NPC, characterized by global DNA hypomethylation (HyperNPC) and global DNA hypermethylation (HypoNPC) respectively. This study aims to develop a cost-effective DNA methylation assay for molecular subtyping and investigating the clinical outcomes of HyperNPC and HypoNPC.