Batatasin I, an active component from tonic Chinese medicine Dioscoreae Rhizoma, mitigates inflammation-related muscle and adipose wasting in pancreatic cancer-associated cachexia
Grant Data
Project Title
Batatasin I, an active component from tonic Chinese medicine Dioscoreae Rhizoma, mitigates inflammation-related muscle and adipose wasting in pancreatic cancer-associated cachexia
Principal Investigator
Professor Wang, Ning
(Principal Investigator (PI))
Co-Investigator(s)
Professor Feng Yibin
(Co-Investigator)
Duration
36
Start Date
2024-11-01
Amount
1497160
Conference Title
Batatasin I, an active component from tonic Chinese medicine Dioscoreae Rhizoma, mitigates inflammation-related muscle and adipose wasting in pancreatic cancer-associated cachexia
Keywords
Dioscoreae Rhizoma, Batatasin I, Cancer Cachexia, Pancreatic Cancer, Muscle and adipose
Discipline
Chinese Medicine (clinical)
HKU Project Code
21222151
Grant Type
Health and Medical Research Fund 2022
Funding Year
2022
Status
On-going
Objectives
Cachexia is characterized by a progressive weight loss resulted from muscle and adipose wasting, which was associated with the poor prognosis of patients with pancreatic cancer. Pro-inflammatory cytokines release by tumour cells under hypoxic condition results in systematic inflammation, inducing abnormal catabolism of skeletal muscle and adipose tissue in cancer patients.