Optogenetic Neuromodulation of Brain-wide Resting-state fMRI Networks and Functions

Professor Wu, Ed Xuekui   (Project Coordinator (PC))

Professor Lai Sau Wan Cora   (Co-principal investigator)

Kim Seong-Gi   (Collaborator)

Zhou Changsong   (Co-principal investigator)

Ko Ho   (Co-principal investigator)

Dr Liang Zhifeng   (Collaborator)

Professor Wong Siu Lun   (Co-principal investigator)

Dr. Lim Lee Wei   (Co-principal investigator)

Dr Leong Tze Lun   (Co-principal investigator)

Professor Lau Gary Kui Kai   (Co-principal investigator)

Professor Chan Ying Shing   (Co-principal investigator)

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2024-03-01

6892140

Optogenetic Neuromodulation of Brain-wide Resting-state fMRI Networks and Functions

1) Magnetic Resonance Imaging 2) Resting-state fMRI 3) Brain Networks 4) Optogenetics 5) Neuromodulation

Imaging

Biology and Medicine (M)

C7052-23G

Collaborative Research Fund (CRF) - Group Research Project 2023/2024

2024

On-going

1. To develop and implement optogenetic neuromodulation methodology that enables concurrentmanipulation of excitatory and inhibitory neurons in rodent models with simultaneous brainwide resting-state fMRI (rsfMRI) and electrophysiological measurements in our 7 Tesla MRIsystem.2. To systematically characterize the effects of optogenetically-manipulated neural activity intwo distinct networks—thalamo-cortical and hippocampal-cortical—on brain-wide rsfMRInetworks and reveal underlying causal neural events through multi-site, multi-depthelectrophysiological recordings and analysis.3. To examine the functional effects of optogenetically-manipulated neural activity in thethalamo-cortical and hippocampal-cortical networks on behavior (e.g., memory functions), anddetermine the causal associations between rsfMRI functional connectivity changes andbehavioral outcomes.