Targeting MVD of the mevalonate pathway induces ferroptosis as a therapeutic strategy against hepatocellular carcinoma

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Grant Data
Project Title
Targeting MVD of the mevalonate pathway induces ferroptosis as a therapeutic strategy against hepatocellular carcinoma
Principal Investigator
Dr Cheu, Wing Sum   (Principal Investigator (PI))
Co-Investigator(s)
Professor Wong Carmen Chak Lui   (Co-principal investigator)
Dr. CHAN Yuen Ki   (Co-Investigator)
Duration
36
Start Date
2023-09-01
Amount
1499888
Conference Title
Targeting MVD of the mevalonate pathway induces ferroptosis as a therapeutic strategy against hepatocellular carcinoma
Keywords
Hepatocellular carcinoma, Ferroptosis, Lipid peroxidation, Mevalonate pathway, Coenzyme Q10
Discipline
Others - Medicine, Dentistry and Health
Panel
Biology and Medicine (M)
HKU Project Code
10212546
Grant Type
Health and Medical Research Fund 2021
Funding Year
2022
Status
On-going
Objectives
Evaluate the clinical significance and understand the regulation of MVD in human HCC. Determine the functional roles of MVD and evaluate the efficacy of MVD inhibition in combination with conventional therapeutics for HCC treatment.