Suppression of Host Innate Immune Response by severe respiratory syndrome coronavirus 2 ORF3a protein via Induction of IKKε dependent autophagy
Grant Data
Project Title
Suppression of Host Innate Immune Response by severe respiratory syndrome coronavirus 2 ORF3a protein via Induction of IKKε dependent autophagy
Principal Investigator
Dr Fung, Sin Yee
(Principal Investigator (PI))
Co-Investigator(s)
Professor Yeung Man Lung
(Co-principal investigator)
Duration
36
Start Date
2023-09-01
Amount
1386852
Conference Title
Suppression of Host Innate Immune Response by severe respiratory syndrome coronavirus 2 ORF3a protein via Induction of IKKε dependent autophagy
Keywords
ORF3a, SARS-CoV-2, COVID-19, TBK1, IKKε
Discipline
Allergy/Immunology
Panel
Biology and Medicine (M)
HKU Project Code
22211042
Grant Type
Health and Medical Research Fund 2021
Funding Year
2022
Status
On-going
Objectives
Recurrent outbreaks of severe respiratory syndrome coronavirus 2 (SARS2) pose a global public health emergency. Type I interferon (IFN-I) production is dampened during SARS2 infection. Evading IFN-I-mediated immune activation benefits SARS-CoV2 infection. Exactly how SARS2 and its ORF3a protein suppress IFN-I to facilitate viral replication and pathogenesis remains to be elucidated.