Development of Chemical Probes for YEATS2 and Their Uses in Mechanistic and Pharmacological Studies
Grant Data
Project Title
Development of Chemical Probes for YEATS2 and Their Uses in Mechanistic and Pharmacological Studies
Principal Investigator
Professor Li, Xiang David
(Principal Investigator (PI))
Co-Investigator(s)
Professor Li Xiaoyu
(Co-principal investigator)
Professor Wong Chun Ming
(Co-principal investigator)
Li Haitao
(Co-Investigator)
Duration
36
Start Date
2023-06-01
Amount
8550000
Conference Title
Development of Chemical Probes for YEATS2 and Their Uses in Mechanistic and Pharmacological Studies
Keywords
1) YEATS2 2) YEATS domain inhibitors 3) DNA-encoded library 4) PROTAC 5) epigenetic reader
Discipline
Chemical SciencesBiochemistry
Panel
Physical Sciences (P)
HKU Project Code
C7016-22G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project 2022/2023
Funding Year
2022
Status
On-going
Objectives
1. To identify YEATS2 YEATS domain inhibitors through the selection of DNA-encoded library. 2. To develop proteolysis-targeting chimeras of YEATS2. 3. To interrogate the YEATS domain-dependent functions of YEATS2 in gene regulation. 4. To examine the anti-cancer effects of YEATS2-targeting molecules.