Development of novel vaccine candidate and passive immunotherapy against multidrug-resistant hypervirulent Klebsiella pneumoniae
Grant Data
Project Title
Development of novel vaccine candidate and passive immunotherapy against multidrug-resistant hypervirulent Klebsiella pneumoniae
Principal Investigator
Dr Liu, Han
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chen Sheng
(Co-principal investigator)
Professor Li Xuechen
(Co-principal investigator)
Duration
36
Start Date
2023-06-01
Amount
1480684
Conference Title
Development of novel vaccine candidate and passive immunotherapy against multidrug-resistant hypervirulent Klebsiella pneumoniae
Keywords
Klebsiella pneumoniae, antibacterial vaccine, passive immunotherapy, capsular polysaccharide, synthetic oligosaccharide
Discipline
Chemical Sciences
Panel
Biology and Medicine (M)
HKU Project Code
22210712
Grant Type
Health and Medical Research Fund 2021
Funding Year
2022
Status
On-going
Objectives
To develop novel oligosaccharide conjugate vaccine candidates against the hypervirulent Klebsiella pneumoniae with K1/K2 CPS, and to develop monoclonal antibodies against K1/K2 CPS for the hvKP diagnosis and therapy.