Discovering Microbial Features for Oral Cancer Diagnosis and Prediction
Grant Data
Project Title
Discovering Microbial Features for Oral Cancer Diagnosis and Prediction
Principal Investigator
Professor Huang, Shi
(Principal Investigator (PI))
Co-Investigator(s)
Dr Koohimoghadam Mohamad
(Co-Investigator)
Dr Liu Pei
(Co-principal investigator)
Professor Khoo Ui Soon
(Co-principal investigator)
Professor Su Yuxiong
(Co-principal investigator)
Duration
24
Start Date
2023-08-01
Amount
1499864
Conference Title
Discovering Microbial Features for Oral Cancer Diagnosis and Prediction
Keywords
Oral cancer, FFPE tissue, Microbiome, Diagnosis, Prediction
Discipline
Others - Medicine, Dentistry and Health
Panel
Biology and Medicine (M)
HKU Project Code
10212276
Grant Type
Health and Medical Research Fund 2021
Funding Year
2022
Status
On-going
Objectives
Oral carcinogenesis can lead to microbiome alteration at the site of the tumor tissue, but its potential in diagnosing oral cancer (OC) or predicting the malignant transformation of orally potential malignant disorders (OPMD) remains elusive yet of great clinical significance. We proposed to:1. Apply a new metagenomic pipeline STREAM to profile oral FFPE tissue microbiomes2. Develop a machine-learning microbiome-based model to diagnose and predict OC