Risk of cognitive impairment and microstructural brain alteration, and its genetic regulation in duchenne muscular dystrophy
Grant Data
Project Title
Risk of cognitive impairment and microstructural brain alteration, and its genetic regulation in duchenne muscular dystrophy
Principal Investigator
Dr Chan, Hoi Shan Sophelia
(Principal Investigator (PI))
Co-Investigator(s)
Dr Lochmuller Hanns
(Co-Investigator)
Dr Javed Asif
(Co-Investigator)
Professor Lee Tatia Mei Chun
(Co-Investigator)
Dr Cheung Martin Chi Hang
(Co-Investigator)
Dr Tso Wan Yee Winnie
(Co-Investigator)
Dr Mak Ka Fung Henry
(Co-Investigator)
Dr Zhi Hui
(Co-Investigator)
Dr Ip Patrick
(Co-Investigator)
Duration
24
Start Date
2022-09-01
Amount
1281344
Conference Title
Risk of cognitive impairment and microstructural brain alteration, and its genetic regulation in duchenne muscular dystrophy
Presentation Title
Keywords
Cognitive impairment, Diffusion kurtosis imaging, Diffusion MRI imaging, Duchenne msucular dystrophy, Neurodisabilities, Neuropsychology
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
09202426
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2021
Status
On-going
Objectives
This study aims to evaluate the spectrum of brain impairment and identify the types of Duchenne muscular dystrophy (DMD) mutations and the dystrophin isoforms affected that correlate to the more severe phenotype. We would also like to study the associated microstructural brain changes and the regulatory role of the circulating microRNAs to brain dysfunction in DMD.