Roles of Natural Killer Cells in the Pathogenesis of Sjögren's Syndrome

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Grant Data
Project Title
Roles of Natural Killer Cells in the Pathogenesis of Sjögren's Syndrome
Principal Investigator
Professor Lu, Liwei   (Principal Investigator (PI))
Duration
42
Start Date
2022-01-01
Amount
1175252
Conference Title
Roles of Natural Killer Cells in the Pathogenesis of Sjögren's Syndrome
Keywords
Autoimmunity, Natural Killer Cells, Salivary glands, Sjögren's syndrome
Discipline
RheumatologyAllergy/Immunology
Panel
Biology and Medicine (M)
HKU Project Code
17103821
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
On-going
Objectives
1 To determine the functions of NK cells in ESS pathogenesis; 2 To examine the roles of proinflammatory cytokines and underlying mechanisms in regulating SG NK cell maturation and function; 3 To investigate the therapeutic effects of targeting SG NK cells on ESS development