A double blind randomized controlled trial of non-invasive preimplantation genetic testing for aneuploidy in in vitro fertilisation

Professor Ng, Ernest Hung Yu   (Principal Investigator (PI))

Dr Cheung Hiu Yee Heidi   (Co-Investigator)

Dr Lam Ka Wai   (Co-Investigator)

Professor Yeung William Shu Biu   (Co-Investigator)

Dr Chow Judy Fung Cheung   (Co-Investigator)

36

2021-07-01

1361728

A double blind randomized controlled trial of non-invasive preimplantation genetic testing for aneuploidy in in vitro fertilisation

blastocyst transfer, infertility, IVF, non-invasive preimplantation genetic testing

Others - Medicine, Dentistry and Health

08192196

Health and Medical Research Fund - Full Grant

2020

On-going

Objectives: To compare the live birth rate following embryo selection based on morphology alone compared to morphology and non-invasive preimplantation genetic testing for aneuploidy (NIPGT-A) in infertile women undergoing in vitro fertilization (IVF). Hypothesis to be tested: Embryo selection based on morphology and NIPGT-A results in a higher live birth rate in IVF as compared to morphology alone. Design and subjects: Double-blind randomized controlled trial. Infertile women undergoing IVF will be enrolled. Instruments: not applicable Interventions: Spent culture medium (SCM) of each blastocyst will be frozen individually. Recruited women will be randomly assigned into one of two groups: (1) the intervention group based on morphology and NIPGT-A and (2) the control group based on morphology alone. In the control group, blastocysts with the best quality morphology will be replaced first. In the intervention group, blastocysts with the best morphology and euploid result of SCM will be replaced first. Blastocysts with non-euploid result in the NIPGT-A report will not be discarded and will be transferred with lower priority. Main outcome measures: a live birth per transfer. Data analysis: Comparison of quantitative variables will be performed using Student’s t, while categorical variables will be compared using a Chi-square analysis. All statistical analyses will be performed with the intention to treat and per protocol, and a p value <0.05 will be considered statistically significant. Expected outcome results: Embryo selection based on morphology and NIPGT-A results in a higher live birth rate in IVF as compared to morphology alone.