Transdifferentiation towards expandable neural progenitors without rejuvenation as authentic cell model for age-associated neurodegenerative diseases

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Grant Data
Project Title
Transdifferentiation towards expandable neural progenitors without rejuvenation as authentic cell model for age-associated neurodegenerative diseases
Principal Investigator
Dr Jauch, Ralf   (Principal Investigator (PI))
Co-Investigator(s)
Professor Zhou Zhongjun   (Co-Investigator)
Dr Chan Sau Fong   (Co-Investigator)
Duration
36
Start Date
2021-09-01
Amount
1477032
Conference Title
Transdifferentiation towards expandable neural progenitors without rejuvenation as authentic cell model for age-associated neurodegenerative diseases
Presentation Title
Keywords
Ageing, Directed evolution, Neural stem cells, Protein engineering, Reprogramming, Transdifferentiation
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
08192886
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2020
Status
On-going
Objectives
We aim to invent a method to transdifferentiate human cells to proliferative neural progenitors that retain their donor’s age and hence represent authentic models for age-associated diseases.