Multi-omic profiling and liquid biopsy as frontline diagnostics for children with central nervous system (CNS) and solid tumors
Grant Data
Project Title
Multi-omic profiling and liquid biopsy as frontline diagnostics for children with central nervous system (CNS) and solid tumors
Principal Investigator
Dr Liu, Anthony Pak Yin
(Principal Investigator (PI))
Co-Investigator(s)
Dr Shing Matthew Ming Kong
(Co-Investigator)
Dr Ku Dennis Tak Loi
(Co-Investigator)
Professor Yang Wanling
(Co-Investigator)
Professor Ng Ho Keung
(Co-Investigator)
Professor Chan Godfrey Chi Fung
(Co-Investigator)
Dr Chung Brian Hon Yin
(Co-Investigator)
Duration
36
Start Date
2021-03-15
Amount
4242732
Conference Title
Multi-omic profiling and liquid biopsy as frontline diagnostics for children with central nervous system (CNS) and solid tumors
Presentation Title
Keywords
CNS tumors, DNA methylation array, liquid biopsy, next-generation sequencing, pediatrics, solid tumors
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
PR-HKU-6
Grant Type
Commissioned Paediatric Research at Hong Kong Children's Hospital
Funding Year
2020
Status
On-going
Objectives
Central nervous system (CNS) and extra-CNS solid tumors account for two-third of pediatric cancer. Recent application of multi-omic profiling revealed intertumoral heterogeneity that informs classification and treatment strategies. Circulating tumor DNA (ctDNA) analysis, on the other hand, offers a non-invasive means to detect and track tumor-specific mutations. Our proposed study evaluates the utility of prospectively integrating these novel platforms with conventional diagnostics in pediatric CNS and solid tumors.