The use of small molecules in modulating human endometrial receptivity and embryo implantation
Grant Data
Project Title
The use of small molecules in modulating human endometrial receptivity and embryo implantation
Principal Investigator
Dr Lee, Calvin Kai Fai
(Principal Investigator (PI))
Co-Investigator(s)
Dr Lee Cherie Yin Lau
(Co-Investigator)
Professor Yeung William Shu Biu
(Co-Investigator)
Professor Ng Ernest Hung Yu
(Co-Investigator)
Duration
36
Start Date
2021-01-01
Amount
1194625
Conference Title
The use of small molecules in modulating human endometrial receptivity and embryo implantation
Presentation Title
Keywords
Co-culture, Contraception, Endometrial Receptivity, Implantation, Small molecules
Discipline
Reproduction,Personalized Medicine
Panel
Biology and Medicine (M)
HKU Project Code
17120720
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
On-going
Objectives
1 Use of receptive and non-receptive endometrial epithelial cells to validate putative small molecules from the Library of Pharmacologically Active Compounds (LOPAC) that modulate endometrial receptivity, 2 Synergistic effect of LOPAC on endometrial epithelial and stromal cell functions, 3 Comparative proteomic and metabolomics analysis of endometrial protein expression and secretion: in vitro and in vivo studies.