Developing bio-orthogonal and photo-cross-linkable amino acids for identification of cell-type-specific protein-protein interactions in physiological context
Grant Data
Project Title
Developing bio-orthogonal and photo-cross-linkable amino acids for identification of cell-type-specific protein-protein interactions in physiological context
Principal Investigator
Professor Li, Xiang David
(Principal Investigator (PI))
Duration
36
Start Date
2020-07-01
Amount
1165852
Conference Title
Developing bio-orthogonal and photo-cross-linkable amino acids for identification of cell-type-specific protein-protein interactions in physiological context
Presentation Title
Keywords
Bio-orthogonal, Chemical probes, Host-pathogen interaction, Photo-cross-linking, Protien-protein interactions
Discipline
Biochemistry
Panel
Biology and Medicine (M)
HKU Project Code
17121120
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
On-going
Objectives
1 To devise bifunctional (photo-cross-linkable and bio-orthogonal) non-canonical amino acids for the detection and identification of protein-protein interactions in vitro. 2 To develop a method for selective labeling of bacterial proteome and identification of host-bacteria protein-protein interactions during infection.