Adiponectin-expressing thymic Treg for adoptive immunotherapy in obesity and metabolic diseases

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Grant Data
Project Title
Adiponectin-expressing thymic Treg for adoptive immunotherapy in obesity and metabolic diseases
Principal Investigator
Professor Wang, Yu   (Principal Investigator (PI))
Duration
36
Start Date
2020-08-01
Completion Date
2023-07-31
Amount
996285
Conference Title
Adiponectin-expressing thymic Treg for adoptive immunotherapy in obesity and metabolic diseases
Keywords
Adiponectin, Adipose tissue inflammation, Energy Metabolism, NAFLD, Regulatory T-cells
Discipline
Diabetes/MetabolismAllergy/Immunology
Panel
Biology and Medicine (M)
HKU Project Code
17124420
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
Completed
Objectives
1 To examine the distribution and function of adiponectin-expressing Treg in adipose tissue and liver of WT and AKO mice challenged with HFD. 2 To investigate the detailed molecular events mediated by adiponectin during tTreg formation and maturation within the microenvironment niche of TNCs.