Diamond-A: DIAbetes in Mother and Off-spring with Neurodevelopmental Disorder – ADHD

Professor Wong, Ian Chi Kei   (Principal Investigator (PI))

Mr Man Kenneth   (Co-Investigator)

Dr Leung Wng Cheong   (Co-Investigator)

Dr Ip Patrick   (Co-Investigator)

Professor Tan Kathryn Choon Beng   (Co-Investigator)

Professor Simonoff Emily   (Co-Investigator)

Dr Lai Chia Cheng Edward   (Co-Investigator)

Professor Banaschewski Tobias   (Co-Investigator)

Dr Coghill David   (Co-Investigator)

30

2021-01-01

837006

Diamond-A: DIAbetes in Mother and Off-spring with Neurodevelopmental Disorder – ADHD

ADHD, Blood glucose control, Gestational diabetes, Maternal diabetes mellitus, Paediatrics

Paediatrics,Psychosocial and Behavioural Research

Biology and Medicine (M)

17112020

General Research Fund (GRF)

2020

On-going

1 Research question 1: Are children born to mothers with gestational diabetes mellitus (GDM) and/or pregestational diabetes mellitus (PGDM) at a higher risk of attention-deficit/hyperactivity disorder (ADHD) than mothers without maternal diabetes mellitus (MDM)? Objective 1a: To calculate the rate of ADHD in children of mothers with MDM (GDM and/or PGDM) and to compare this to the rate of ADHD in children of mothers without MDM Objective 1b: To compare the rate of ADHD in children of mothers with GDM and mothers without MDM Objective 1c: To compare the rate of ADHD in children of mothers with PGDM and mothers without MDM. Mothers with PGDM will be further stratified into type-I and type-II diabetes mellitus (DM) 2 Research question 2: Are children born to mothers with GDM at a higher risk of ADHD than mothers with PGDM? Objective 2: To calculate the rate of ADHD in children of mothers with GDM diagnosed only in pregnancy and to compare this to the rate of ADHD in children of mothers with PGDM. Mothers with PGDM will be further stratified into type-I and type-II DM 3 Research question 3: Are children born to mothers with GDM at a higher risk of ADHD than their siblings without exposure to MDM? Objective 3: To compare the rate of ADHD in children of mothers with GDM in that pregnancy episode to their siblings without exposure to MDM 4 Research question 4: Are there any associations between the MDM pharmacological treatments, glycemic control and the risk of ADHD in offspring? Objective 4a: To calculate the rate of ADHD in children of mothers who were treated with antidiabetic medications for MDM (GDM and PGDM) and to compare this to the rate of ADHD in children of mothers with unmedicated MDM. Analysis will also be adjusted for baseline blood glucose level Objective 4b: To investigate different patterns of glycemic control (trajectory) on the incidence of ADHD i.e. the association of blood glucose level and incidence of ADHD using electronic health record (EHR) databases