β-catenin heterogeneity: cellular senescence as driver of widespread metastatic dissemination?
Grant Data
Project Title
β-catenin heterogeneity: cellular senescence as driver of widespread metastatic dissemination?
Principal Investigator
Professor Wong, Alice Sze Tsai
(Principal Investigator (PI))
Co-Investigator(s)
Dr Zhang Jiangwen
(Co-Investigator)
Professor Zhou Zhongjun
(Co-Investigator)
Professor Kang Wei
(Co-Investigator)
Duration
36
Start Date
2021-01-01
Amount
1189444
Conference Title
β-catenin heterogeneity: cellular senescence as driver of widespread metastatic dissemination?
Presentation Title
Keywords
adhesion, functional roles of genes, progression
Discipline
Molecular Biology
Panel
Biology and Medicine (M)
HKU Project Code
17104820
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
On-going
Objectives
1 To unravel the functional roles of β-catenin ITH in different stages of tumor progression 2 To decipher the molecular mechanism of the β-catenin-Hippo signaling axis 3 To delineate the underlying mechanisms of action of β-catenin-low cells in β-catenin-high-driven metastasis, with particular reference to cellular senescence