Sample size re-estimation in adaptive enrichment design and survival analysis with area above quantile
Grant Data
Project Title
Sample size re-estimation in adaptive enrichment design and survival analysis with area above quantile
Principal Investigator
Professor Yin, Guosheng
(Principal Investigator (PI))
Duration
30
Start Date
2020-07-01
Completion Date
2023-12-28
Amount
396967
Conference Title
Sample size re-estimation in adaptive enrichment design and survival analysis with area above quantile
Keywords
adaptive design, enrichment, restricted mean survival time, sample size re-estimation, survival analysis
Discipline
Probability & StatisticsClinical Trials
Panel
Physical Sciences (P)
HKU Project Code
17308420
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
Completed
Objectives
1 We develop adaptive enrichment strategies with sample size re-estimation by controlling the overall type I error rate and achieving desired statistical power with minimum expected sample size. 2 We develop a new measure of survival by assessing the average survival time among the population whose survival rates are greater than a certain quantile, which is the area under the survival curve with respect to the vertical axis in contrast to the restricted mean survival time which is the area under the survival curve along the horizontal axis. 3 For interval-censored and truncated data, we propose a new algorithm to compute the NPMLE by casting the likelihood in the incomplete multinomial framework, and further compute the restricted mean survival time and area above a quatile for such data.