Treatment of highly pathogenic influenza A/H5N1-induced lung injury with mesenchymal stromal cell-derived exosomes
Grant Data
Project Title
Treatment of highly pathogenic influenza A/H5N1-induced lung injury with mesenchymal stromal cell-derived exosomes
Principal Investigator
Professor Chan, Michael Chi Wai
(Principal Investigator (PI))
Co-Investigator(s)
Professor Hui Pui Yan
(Co-Investigator)
Professor Peiris Joseph Sriyal Malik
(Co-Investigator)
Duration
50
Start Date
2020-12-01
Amount
1492780
Conference Title
Treatment of highly pathogenic influenza A/H5N1-induced lung injury with mesenchymal stromal cell-derived exosomes
Keywords
acute lung injury, exosomes, H5N1, influenza, macrophages, mesenchymal stromal cells
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
19180882
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
Treatment of highly pathogenic avian influenza (HPAI) H5N1 has relied on antiviral, yet fails to reduce the severe mortality rate. Mesenchymal stromal cells (MSCs) that has been proposed to treat alveolar edema in pneumonia and other lung diseases still fail to pass multiple clinical trials. The beneficial effect of MSCs has suggested to be delivered by exosomes released by MSCs (MSC-exosomes) containing growth factors and anti-inflammatory cytokines. We propose to investigate the therapeutic efficacy of MSC-exosomes in pre-clinical H5N1-infected mouse model and the role of MSC-exosomes in alveolar fluid clearance and host immune modulation.