Mechanism of MMP14 control of bone mass via chondrocyte to osteoblast conversion

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Grant Data
Project Title
Mechanism of MMP14 control of bone mass via chondrocyte to osteoblast conversion
Principal Investigator
Emeritus Professor Cheah, Kathryn Song Eng   (Principal Investigator (PI))
Co-Investigator(s)
Professor Zhou Zhongjun   (Co-Investigator)
Duration
53
Start Date
2020-05-01
Amount
1500000
Conference Title
Mechanism of MMP14 control of bone mass via chondrocyte to osteoblast conversion
Keywords
Bone mass regulation, Cartilage, MMP14, Mouse Model, PTH signaling, Skeletal Progenitors
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
07183766
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
i) Determine the mechanism of MMP14-mediated PTH control of HC-OB lineage and their contribution to bone homeostasis during lifespan. ii) Identify MMP14 targets in HC-OB lineage, develop a MMP14 osteogenic gene regulatory network (GRN) model.