Development of photo-targeted nanocarriers for esophageal cancer therapy
Grant Data
Project Title
Development of photo-targeted nanocarriers for esophageal cancer therapy
Principal Investigator
Professor Wang, Weiping
(Principal Investigator (PI))
Co-Investigator(s)
Professor Law Simon Ying Kit
(Co-Investigator)
Duration
36
Start Date
2020-09-01
Amount
1405630
Conference Title
Development of photo-targeted nanocarriers for esophageal cancer therapy
Keywords
Esophageal cancer, Photoresponsive, Photo-targeted nanoparticles, Phototriggered targeting, Stimuli-responsive, Targeted drug delivery
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
07181936
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
We aim to develop near infrared (NIR) light-responsive nanocarriers that can target esophageal squamous cell carcinoma (ESCC) upon light irradiation with optical fibers. Hypothesis to be tested: NIR light can remove the photocleavable groups and activate the binding function of cell-penetrating peptides (CPPs), which triggers nanocarrier accumulation in tumors. Design and subjects: We will develop photo-targeted polymeric nanocarriers with CPPs deactivated by a photocleavable BODIPY group. The BODIPY group can be removed by 656 nm NIR light. The phototargeting effect and therapeutic efficacy of the nanocarriers will be evaluated in an orthotopic ESCC mouse model. Study instruments: Optical fiber-coupled LED system and in vivo imaging system (IVIS).