Investigation of rat hepatitis E virus and genotype 4 hepatitis E virus infections among immunocompromised persons, patients with hepatitis and rats in Hong Kong
Grant Data
Project Title
Investigation of rat hepatitis E virus and genotype 4 hepatitis E virus infections among immunocompromised persons, patients with hepatitis and rats in Hong Kong
Principal Investigator
Dr Sridhar, Siddharth
(Principal Investigator (PI))
Co-Investigator(s)
Professor Woo Patrick Chiu Yat
(Co-Investigator)
Dr Yip Chik Yan
(Co-Investigator)
Professor Yuen Kwok Yung
(Co-Investigator)
Duration
36
Start Date
2020-07-01
Amount
699834
Conference Title
Investigation of rat hepatitis E virus and genotype 4 hepatitis E virus infections among immunocompromised persons, patients with hepatitis and rats in Hong Kong
Presentation Title
Keywords
hepatitis, hepatitis E, immunocompromised persons, rodent, zoonosis
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
19180442
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
We recently demonstrated that genotype 4 hepatitis E virus (HEV-4) and rat HEV (HEV-C) infect immunocompromised individuals in Hong Kong. The primary objective of this project is to evaluate HEV-4 and HEV-C infection prevalence in Hong Kong residents. Secondary objectives are to understand clinical characteristics of infection due to these HEV variants, evaluate prevalence of HEV-C among local rats, and understand routes of rat-to-human HEV-C transmission.