Alterations in classical and exhausted memory B cells in lupus nephritis - role in disease stability and effect of immunosuppressive treatments
Grant Data
Project Title
Alterations in classical and exhausted memory B cells in lupus nephritis - role in disease stability and effect of immunosuppressive treatments
Principal Investigator
Professor Yap, Yat Hin Desmond
(Principal Investigator (PI))
Co-Investigator(s)
Dr Wong Yik Hei Patrick
(Co-Investigator)
Professor Chan Daniel Tak Mao
(Co-Investigator)
Dr Cheung Chi Yuen
(Co-Investigator)
Professor Yung Susan Sou Ying
(Co-Investigator)
Duration
36
Start Date
2020-07-01
Amount
1499244
Conference Title
Alterations in classical and exhausted memory B cells in lupus nephritis - role in disease stability and effect of immunosuppressive treatments
Keywords
exhaustion, immunosuppression, Lupus nephritis, Memory B cells, relapse
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
07183786
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
Repeated relapses confer unfavorable outcomes in lupus nephritis (LN) patients. Alterations in classical and exhausted memory B cells can lead to abnormal B cell responses, and our pilot data showed higher classical memory-to-naïve B cell ratio and increased exhausted memory B cells in LN patients with multiple relapses compared to non-relapsers. This project aims to investigate the role of classical and exhausted memory B cells in LN relapse and the effect of immunosuppressive treatments.