Discovery of metallo-agents as antimicrobial resistance breakers

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Grant Data
Project Title
Discovery of metallo-agents as antimicrobial resistance breakers
Principal Investigator
Professor Sun, Hongzhe   (Principal Investigator (PI))
Co-Investigator(s)
Dr De Reuse Hilde   (Co-principal investigator)
Dr Wang Runming   (Co-Investigator)
Duration
36
Start Date
2020-02-01
Completion Date
2023-01-31
Amount
54000
Conference Title
Discovery of metallo-agents as antimicrobial resistance breakers
Keywords
antimicrobial, Discovery, metallo-agents, resistance breakers
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
F-HKU704/19
Grant Type
France/Hong Kong Joint Research Scheme - Travel Grants
Funding Year
2019
Status
Completed
Objectives
1.Synthesis of 5~10 Bi(III) and Ga(III) complexes with oxygen, nitrogen and/or sulfur-containing ligands. 2.Identify 1~2 active compound(s) that exhibit potent antimicrobial activity against antibiotic resistant bacterial pathogens. 3.Provide a comprehensive profile of Bi(III) or Ga(III) binding proteins in an antibiotic-resistant strain.