Novel approaches to combating the keystone periodontopathogen Porphyromonas gingivalis in infected host cells via multi-omic integrative analyses
Grant Data
Project Title
Novel approaches to combating the keystone periodontopathogen Porphyromonas gingivalis in infected host cells via multi-omic integrative analyses
Principal Investigator
Professor Jin, Lijian
(Principal Investigator (PI))
Co-Investigator(s)
Professor Sun Hongzhe
(Co-Investigator)
Dr Cheng Tianfan
(Co-Investigator)
Duration
36
Start Date
2019-10-31
Completion Date
2022-10-30
Amount
1116019
Conference Title
Novel approaches to combating the keystone periodontopathogen Porphyromonas gingivalis in infected host cells via multi-omic integrative analyses
Keywords
bismuth drugs, host response, omics, Periodontitis, Porphyromonas gingivalis
Discipline
DentistryInfection/Parasitology
Panel
Biology and Medicine (M)
HKU Project Code
17119819
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To investigate the effects of bismuth drugs on the transcriptomic, proteomic and secretomic profiles of various P. gingivalis strains-infected host cells including oral/periodontal epithelial cells, endothelial cells, neuronal cells, macrophages and neutrophils. 2 To reveal the underlying signaling pathways involved in bismuth drug treatments of P. gingivalis-infected host cells. 3 To evaluate the regulating effects of micro-environmental factors like hemin levels on P. gingivalis-infected host cells during the treatments of bismuth drugs and related molecular mechanisms.