Inhibitory effect of the natural compound fangchinoline from Stephania tetrandra S. Moore on human liver cancer stem cells

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Grant Data
Project Title
Inhibitory effect of the natural compound fangchinoline from Stephania tetrandra S. Moore on human liver cancer stem cells
Principal Investigator
Professor Feng, Yibin   (Principal Investigator (PI))
Co-Investigator(s)
Professor Guan Xin-Yuan   (Co-Investigator)
Dr Ho Daniel Sai Yin   (Co-Investigator)
Dr Wang Ning   (Co-Investigator)
Duration
36
Start Date
2019-12-01
Completion Date
2022-11-30
Amount
1181602
Conference Title
Inhibitory effect of the natural compound fangchinoline from Stephania tetrandra S. Moore on human liver cancer stem cells
Keywords
Cancer drug resistance, CD133+ cancer stem cells, Fangchinoline, hepatocellular carcinoma, WT1
Discipline
Traditional Chinese Medicine (basic)Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17121419
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To validate the inhibition of in vivo tumorigenicity of CD133+ CSCs by fangchinoline alone and in combination with chemotherapeutics 2 To investigate the role of WT1 in mediating the suppressive effect of fangchinoline on CD133+ CSCs 3 To elucidate the regulatory mechanism of fangchinoline on the upstream and downstream signalling of WT1