Role of interleukin-25 in the pathogenesis of experimental Sjögren’s syndrome

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Grant Data
Project Title
Role of interleukin-25 in the pathogenesis of experimental Sjögren’s syndrome
Principal Investigator
Professor Lu, Liwei   (Principal Investigator (PI))
Duration
48
Start Date
2020-01-01
Amount
1152518
Conference Title
Role of interleukin-25 in the pathogenesis of experimental Sjögren’s syndrome
Keywords
Autoimmunity, B cell, Interleukin-25, Sjögren's syndrome
Discipline
RheumatologyAllergy/Immunology
Panel
Biology and Medicine (M)
HKU Project Code
17113319
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
On-going
Objectives
1 To examine a role of IL-25 in regulating B cell maturation and function 2 To determine the role of IL-25 in regulating plasma cell response during ESS development 3 To elucidate the molecular mechanisms of IL-25-mediated plasma cell survival and function 4 To explore the novel therapeutic strategies by targeting IL-25 in ESS mice