Targeting lactate dehydrogenase A for extranodal NK/T-cell lymphoma therapy
Grant Data
Project Title
Targeting lactate dehydrogenase A for extranodal NK/T-cell lymphoma therapy
Principal Investigator
Dr Au Yeung, Kwok Him Rex
(Principal Investigator (PI))
Co-Investigator(s)
Professor Tse Eric Wai Choi
(Co-Investigator)
Dr Liu Jing
(Co-Investigator)
Duration
36
Start Date
2019-05-01
Amount
1163176
Conference Title
Targeting lactate dehydrogenase A for extranodal NK/T-cell lymphoma therapy
Presentation Title
Keywords
dehydrogenase, extranodal, lactate, lymphoma, NK/T-cell, Targeting
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06173066
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
On-going
Objectives
Extranodal natural killer/T-cell lymphoma, nasal type, (ENKTL) represents an aggressive clinical course and a poor prognosis especially for advanced disease. Better understanding of the metabolic machineries of ENKTL will be beneficial for finding novel biomarkers or agents for the development of therapeutic treatment. Our preliminary data showed that Lactate Dehydrogenase A (LDHA) was activated in ENKTL. Thus, our objective is to characterize the function of LDHA in ENKTL and investigate the feasibility to use LDHA inhibitor for ENKTL treatment.