Evaluation of disease severity of seasonal influenza viruses using human respiratory tract explant cultures, lung injury models, and correlation with glycosylation status

Professor Nicholls, John Malcolm   (Principal Investigator (PI))

Dr Chan Michael Chi Wai   (Co-Investigator)

Dr Hui Pui Yan   (Co-Investigator)

Professor Peiris Joseph Sriyal Malik   (Co-Investigator)

36

2019-07-01

1189520

Evaluation of disease severity of seasonal influenza viruses using human respiratory tract explant cultures, lung injury models, and correlation with glycosylation status

Evaluation, explant, glycosylation, influenza, severity, viruses

Others - Medicine, Dentistry and Health

18170922

Health and Medical Research Fund - Full Grant

2018

On-going

Previously we have used two clinically relevant risk assessment models, a WHO recognized ex vivo explant culture of the human respiratory tract, and an in vitro lung injury model alveolar fluid clearance as indicator of tropism and acute lung injury. In this submission we propose to utilize these systems to access whether there is a correlate between the severity and tropism of seasonal influenza viruses with mortality and morbidity.