Genome-wide DNA-methylation profiling as frontline diagnostic test for central nervous system embryonal tumors in children
Grant Data
Project Title
Genome-wide DNA-methylation profiling as frontline diagnostic test for central nervous system embryonal tumors in children
Principal Investigator
Dr Liu, Anthony Pak Yin
(Principal Investigator (PI))
Co-Investigator(s)
Professor Ng Ho Keung
(Co-Investigator)
Dr Chung Brian Hon Yin
(Co-Investigator)
Professor Yang Wanling
(Co-Investigator)
Professor Chan Godfrey Chi Fung
(Co-Investigator)
Duration
36
Start Date
2019-09-01
Completion Date
2023-11-13
Amount
1327197
Conference Title
Genome-wide DNA-methylation profiling as frontline diagnostic test for central nervous system embryonal tumors in children
Keywords
diagnostic, DNA-methylation, embryonal, frontline, nervous, tumors
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06171666
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
Completed
Objectives
Central nervous system (CNS) embryonal tumors are common pediatric brain tumors with poor outcome. Recent application of genome-wide DNA methylation profiling revealed clinically relevant subclasses as well as new entities that could not be readily defined by conventional methods. There is paucity of knowledge as to how these newly defined methylation classes relate to patient outcome when they are managed uniformly with standard treatment protocols.