The role of PDGFR and the therapeutic potential of its inhibitor in MERS-CoV infection
Grant Data
Project Title
The role of PDGFR and the therapeutic potential of its inhibitor in MERS-CoV infection
Principal Investigator
Dr Hui, Pui Yan
(Principal Investigator (PI))
Co-Investigator(s)
Professor Peiris Joseph Sriyal Malik
(Co-Investigator)
Dr Chan Michael Chi Wai
(Co-Investigator)
Professor Nicholls John Malcolm
(Co-Investigator)
Duration
42
Start Date
2019-09-01
Amount
1499220
Conference Title
The role of PDGFR and the therapeutic potential of its inhibitor in MERS-CoV infection
Presentation Title
Keywords
infection, inhibitor, MERS-CoV, PDGFR, potential, therapeutic
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
18170882
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
On-going
Objectives
There is no effective clinically proven antiviral or treatment against MERS-CoV. Supportive care remains the predominant treatment for the patients. This study will investigate the antiviral, immunomodulatory effects and the roles of PDGFR in MERS-CoV infection, including a recent human isolate in Korea 2015 using in vitro models. We will also evaluate the therapeutic potential of a clinically used PDGFR inhibitor in Korean MERS-CoV infection using mice transfected for human DPP4 receptor.