Tropism and pathogenesis of the highly pathogenic avian influenza A/H7N9 virus in human respiratory tract and potential therapeutic effect of interferon and cyclophilin inhibitors
Grant Data
Project Title
Tropism and pathogenesis of the highly pathogenic avian influenza A/H7N9 virus in human respiratory tract and potential therapeutic effect of interferon and cyclophilin inhibitors
Principal Investigator
Dr Chan, Michael Chi Wai
(Principal Investigator (PI))
Co-Investigator(s)
Professor Peiris Joseph Sriyal Malik
(Co-Investigator)
Professor Nicholls John Malcolm
(Co-Investigator)
Duration
36
Start Date
2019-03-26
Amount
1299520
Conference Title
Tropism and pathogenesis of the highly pathogenic avian influenza A/H7N9 virus in human respiratory tract and potential therapeutic effect of interferon and cyclophilin inhibitors
Presentation Title
Keywords
avian, cyclophilin, pathogenesis, respiratory, therapeutic, Tropism
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
18170792
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
On-going
Objectives
Influenza A/H7N9 virus has caused five epidemics in China since its first detection in 2013. In 2017, the previously low pathogenic avian influenza (LPAI) H7N9 virus underwent mutation in its haemagglutinin to give a highly pathogenic avian influenza (HPAI) virus causing 32 human cases and potentially poses a threat to animal and human health.