Endothelial SIRT1 - a key circadian regulator controlling the 24-hour rhythmicity in blood pressure and energy metabolism
Grant Data
Project Title
Endothelial SIRT1 - a key circadian regulator controlling the 24-hour rhythmicity in blood pressure and energy metabolism
Principal Investigator
Professor Wang, Yu
(Principal Investigator (PI))
Co-Investigator(s)
Professor Vanhoutte Paul Michel Georges Remi
(Co-Investigator)
Duration
48
Start Date
2019-01-01
Completion Date
2022-12-31
Amount
1486164
Conference Title
Endothelial SIRT1 - a key circadian regulator controlling the 24-hour rhythmicity in blood pressure and energy metabolism
Keywords
Circadian clock, Endothelial cells, Leucine metabolism, Posttranslational modification, SIRT1
Discipline
Cardiovascular ResearchAgeing
Panel
Biology and Medicine (M)
HKU Project Code
17124718
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 Does overexpression of human SIRT1 in endothelial cells facilitate the metabolism of BCAA (in particular leucine) by modulating the 24-hour circadian expressions of key enzymes in peripheral tissues? 2 Does timely enhanced leucine metabolism contribute to the 24-hour oscillations of body temperature and arterial blood pressure in mice with endothelial overexpression of human SIRT1? 3 How does SIRT1 expression and activity oscillate with leucine metabolism and/or body temperature changes in peripheral organs?