A bioinformatics framework to identify cooperation of transcription factors in regulating cancer progression

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Grant Data
Project Title
A bioinformatics framework to identify cooperation of transcription factors in regulating cancer progression
Principal Investigator
Dr Yan, Bin   (Principal Investigator (PI))
Co-Investigator(s)
Dr Xia Zhengyuan   (Co-Investigator)
Professor Irwin Michael Garnet   (Co-Investigator)
Duration
36
Start Date
2018-09-01
Amount
971190
Conference Title
A bioinformatics framework to identify cooperation of transcription factors in regulating cancer progression
Presentation Title
Keywords
bioinformatics model, gene regulation, head & neck cancer progression, regulatory genomic variants, Transcription factor
Discipline
Others - Biological Sciences,Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17117918
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To test and improve Logic-Stage for identifying TF logics in regulating target genes during different biological stages. 2 To analyze the effect of TF binding- regulatory GV interactions on gene regulation, apply this interaction to our framework to identify target genes of TF logics 3 To experimentally and functionally validate the predicted TF logics targets in HNSCC tissues and cell lines